Herpesvirus‐Mimicking DNAzyme‐Loaded Nanoparticles as a Mitochondrial DNA Stress Inducer to Activate Innate Immunity for Tumor Therapy

X Zhao, Y Wang, W Jiang, Q Wang, J Li… - Advanced …, 2022 - Wiley Online Library
Virus‐based immunotherapy is a promising approach to treat tumor. Closely mimicking the
structure and sequential infection processes of natural viruses is highly desirable for …

Bio-inspired engineering of cell-and virus-like nanoparticles for drug delivery

A Parodi, R Molinaro, M Sushnitha, M Evangelopoulos… - Biomaterials, 2017 - Elsevier
The engineering of future generations of nanodelivery systems aims at the creation of
multifunctional vectors endowed with improved circulation, enhanced targeting and …

Facile synthesis of uniform virus-like mesoporous silica nanoparticles for enhanced cellular internalization

W Wang, P Wang, X Tang, AA Elzatahry… - ACS central …, 2017 - ACS Publications
The low-efficiency cellular uptake property of current nanoparticles greatly restricts their
application in the biomedical field. Herein, we demonstrate that novel virus-like mesoporous …

Evaluation of mesoporous silica nanoparticles for oral drug delivery–current status and perspective of MSNs drug carriers

J Florek, R Caillard, F Kleitz - Nanoscale, 2017 - pubs.rsc.org
The oral pathway is considered as the most common method for drug administration,
although many drugs, especially the highly pH-and/or enzymatic biodegradable peptide …

Silica nanopollens enhance adhesion for long-term bacterial inhibition

H Song, Y Ahmad Nor, M Yu, Y Yang… - Journal of the …, 2016 - ACS Publications
Nature's creations with spiky topological features typically exhibit intriguing surface adhesive
properties. From micrometer-sized pollen grains that can easily stick to hairy insects for …

Tumor microenvironment responsive shape-reversal self-targeting virus-inspired nanodrug for imaging-guided near-infrared-II photothermal chemotherapy

Y Li, J Lin, P Wang, Q Luo, H Lin, Y Zhang, Z Hou… - Acs Nano, 2019 - ACS Publications
Tumor microenvironment responsive multimodal synergistic theranostic strategies can
significantly improve the therapeutic efficacy while avoiding severe side effects. Inspired by …

Deformable hollow periodic mesoporous organosilica nanocapsules for significantly improved cellular uptake

Z Teng, C Wang, Y Tang, W Li, L Bao… - Journal of the …, 2018 - ACS Publications
Mesoporous solids have been widely used in various biomedical areas such as drug
delivery and tumor therapy. Although deformability has been recognized as a prime …

Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma

M Yan, Q Chen, T Liu, X Li, P Pei, L Zhou… - Nature …, 2023 - nature.com
Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer
(TNBC). However, the limited tumor penetration and low cellular internalization efficiency of …

Rattle-Structured Rough Nanocapsules with in-Situ-Formed Gold Nanorod Cores for Complementary Gene/Chemo/Photothermal Therapy

X Chen, Q Zhang, J Li, M Yang, N Zhao, FJ Xu - ACS nano, 2018 - ACS Publications
The morphology of nanoparticles influences their cellular uptake process, while rough
surface-enhanced affinity renders rough nanoparticles desirable in related biomedical …

Tumor Microenvironment-Responsive Yolk–Shell NaCl@Virus-Inspired Tetrasulfide-Organosilica for Ion-Interference Therapy via Osmolarity Surge and Oxidative …

Y Li, J Lin, P Wang, F Zhu, M Wu, Q Luo, Y Zhang… - ACS …, 2022 - ACS Publications
Ion-interference therapy, which utilizes ions to disturb intracellular biological processes,
provides inspiration for tumor therapy. Artificially reversing osmotic pressure by transporting …