Depression and obesity have high concurrence within individuals, which may be explained
by sharing the same risk factors, including disruption of the intestinal microbiota. However …

Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

Ursolic acid, a constituent from Rosmarinus officinalis, is a triterpenoid compound which has
been extensively known for its anticancer and antioxidant properties. In the present study …

The present study investigated the antinociceptive effects of the flavonoid myricitrin in
chemical behavioral models of pain in mice and rats. Myricitrin given by ip or po routes …

Major depressive disorder is a common but devastating mental disorder, and recent
evidence shows that neuroinflammation may play a pivotal role in the etiology of depression …

Rationale Few studies have investiga. ted whether the behavioral effects elicited by different
types of antidepressant drugs are mediated by either serotonin (5-HT) or the catecholamines …

Abstract Carvacrol (5‐isopropyl‐2‐methylphenol) is a monoterpenic phenol present in the
essential oil of many plants. It is the major component of the essential oil fraction of oregano …

Dehydrocorydaline (DHC) is an alkaloidal component isolated from Rhizoma corydalis.
Previous studies have shown that DHC has anti-inflammatory and anti-tumor effects and that …

Ascorbic acid is highly concentrated in the brain, being considered as a neuromodulator.
This study investigated the effect of ascorbic acid in the tail suspension test (TST) and in the …

The antinociceptive action of quercetin, a common bioactive flavonoid present in many
medicinal plants, was assessed in different models of chemical and thermal nociception in …