Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives

RC Dutra, MM Campos, ARS Santos… - Pharmacological research, 2016 - Elsevier
This review article focuses on pre-clinical and clinical studies with some selected Brazilian
medicinal plants in different areas of interest, conducted by research groups in Brazil and …

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice

JF Cryan, C Mombereau, A Vassout - Neuroscience & Biobehavioral …, 2005 - Elsevier
Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders

ZJ Zhang - Life sciences, 2004 - Elsevier
A search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has
progressed significantly in the past decade. This is reflected in the large number of herbal …

Antidepressant properties of bioactive fractions from the extract of Crocus sativus L.

Y Wang, T Han, Y Zhu, CJ Zheng, QL Ming… - Journal of natural …, 2010 - Springer
The aim of this study was to investigate the antidepressant properties of stigmas and corms
of Crocus sativus L. The aqueous ethanol extract of C. sativus corms was fractionated on the …

Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic …

DG Machado, LEB Bettio, MP Cunha… - European Journal of …, 2008 - Elsevier
We have recently shown that the hexanic extract from leaves of Schinus molle produces
antidepressant-like effects in the tail suspension test in mice. This study investigated the …

[HTML][HTML] Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression

JE Ghia, P Blennerhassett… - The Journal of clinical …, 2008 - Am Soc Clin Investig
Clinical and experimental evidence indicates that intestinal inflammatory conditions can be
exacerbated by behavioral conditions such as depression. The recent demonstration of a …

[HTML][HTML] Phytochemistry and pharmacology of anti-depressant medicinal plants: A review

J Martins, S Brijesh - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Stress renders an individual to experience mental pressure and exhaustion which brings
about feelings of anxiety, depression, anger and/or other negative emotions. Depression …

Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests

D Dhingra, A Sharma - Progress in Neuro-Psychopharmacology and …, 2006 - Elsevier
The present study was undertaken to investigate the effects of aqueous extract of Glycyrrhiza
glabra L.(Family: Fabaceae), popularly known as liquorice, on depression in mice using …

Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system

DG Machado, LEB Bettio, MP Cunha, JC Capra… - Progress in Neuro …, 2009 - Elsevier
Rosemary, Rosmarinus officinalis L.(Labiatae) has several therapeutic applications in folk
medicine in curing or managing a wide range of diseases, including depression. In this …

[HTML][HTML] Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice

CH Chiu, CC Chyau, CC Chen, LY Lee… - International journal of …, 2018 - mdpi.com
Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium
enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) …