Over 100 types of chemical modifications have been identified in cellular RNAs. While the
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …

Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

Abstract How N 6-methyladenosine (m6A), the most abundant mRNA modification,
contributes to primate tissue homeostasis and physiological aging remains elusive. Here …

Myosteatosis, or pathological excess fat accumulation in muscle, has been widely defined
as a lower mean skeletal muscle radiodensity on computed tomography (CT). It is reported …

Impaired gene regulation lies at the heart of many disorders, including developmental
diseases and cancer. Furthermore, the molecular pathways that control gene expression are …

Over the past several decades, RNA modifications have rapidly emerged as an
indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation …

Purpose The fat mass-and obesity-associated (FTO) gene on chromosome 16q12. 2 shows
an intimate association with obesity and body mass index. Recently, research into the FTO …

Obesity has reached epidemic proportions globally. Although modern adoption of a
sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause …

Abstract N6-methyladenosine (m6A) RNA methylation is an emerging area of epigenetics,
which is a reversible and dynamic modification mediating by 'writers'(methylase, adding …

Summary N6‐methyladenine (m6A) is the most prevalent type of internal RNA methylation in
eukaryotic mRNA and plays critical roles in regulating gene expression for fundamental …