Perioperative pulmonary atelectasis: part I. Biology and mechanisms

C Zeng, D Lagier, JW Lee, MF Vidal Melo - Anesthesiology, 2022 - pubs.asahq.org
Pulmonary atelectasis is common in the perioperative period. Physiologically, it is produced
when collapsing forces derived from positive pleural pressure and surface tension overcome …

Optimized ventilation strategy for surgery on patients with obesity from the perspective of lung protection: A network meta-analysis

J Wang, J Zeng, C Zhang, W Zheng, X Huang… - Frontiers in …, 2022 - frontiersin.org
Objectives New ventilation modes have been proposed to support the perioperative
treatment of patients with obesity, but there is a lack of consensus regarding the optimal …

Effects of PEEP on regional ventilation-perfusion mismatch in the acute respiratory distress syndrome

B Pavlovsky, A Pesenti, E Spinelli, G Scaramuzzo… - Critical Care, 2022 - Springer
Purpose In the acute respiratory distress syndrome (ARDS), decreasing Ventilation-
Perfusion V˙/Q˙ mismatch might enhance lung protection. We investigated the regional …

Pathophysiological profile of non-ventilated lung injury in healthy female pigs undergoing mechanical ventilation

E Spinelli, A Damia, F Damarco, B Gregori… - Communications …, 2024 - nature.com
Background Lung regions excluded from mechanical insufflation are traditionally assumed
to be spared from ventilation-associated lung injury. However, preliminary data showed …

Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions

A Rashid, C Zeng, G Motta-Ribeiro, ST Dillon… - Scientific Reports, 2022 - nature.com
Atelectasis is a frequent clinical condition, yet knowledge is limited and controversial on its
biological contribution towards lung injury. We assessed the regional proteomics of …

RNA Sequencing: The Twenty-first Century Stethoscope in Pulmonary Medicine

E Lucchinetti, M Zaugg - Anesthesiology, 2020 - pubs.asahq.org
LUNG atelectasis was first described by the French physician René Théophile Hyacinthe
Laënnec in his iconic book entitled, De L'Auscultation Médiate; ou Traité du Diagnostic des …

Alveolar Collapse as a Threat to Mechanically Ventilated Lungs

E Spinelli, T Mauri - American Journal of Respiratory and Critical …, 2024 - atsjournals.org
Alveolar collapse is a hallmark of acute respiratory distress syndrome (ARDS), with multiple
causative mechanisms (1). First, the initial inflammation triggers extravasation of …

Isomer-Specific Effects of cis-9,trans-11- and trans-10,cis-12-CLA on Immune Regulation in Ruminal Epithelial Cells

C Yang, B Zhu, S Ye, Z Fu, J Li - Animals, 2021 - mdpi.com
Simple Summary The significant contribution of rumen microbiota to the balance of the
innate immunity of rumen epithelium has been extensively verified. As the natural rumen …

Roles for Hippo pathway effectors Taz and Yap in cancer and fibrosis

N Kingston - 2022 - search.proquest.com
The Hippo pathway is a well-conserved signaling pathway composed of a series of kinases,
ending in the LATS1 and LATS2 kinases (LATS1/2), that control the activity of the …