Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant
granulocyte population in mammals. The relative rarity of basophils and their phenotypic …

Allergic rhinitis (AR), a chronic inflammatory disease of the upper airway, is one of the most
common chronic diseases in the United States and is estimated to affect up to 60 million …

Allergic rhinitis (AR; also nasal allergies or “hay fever”) is a chronic upper airway
inflammatory disease that affects∼ 60 million adults and children in the United States. The …

Background Dupilumab, an anti–IL-4 receptor α mAb, inhibits IL-4/IL-13 signaling, key
drivers of type 2/TH 2 immune diseases (eg, atopic/allergic disease). In a pivotal, phase 2b …

Objective Animal models of asthma mimic major features of human disease. Since the
genetic background of experimental animals might affect hyperresponsiveness and …

Ethnopharmacological relevance Asthma is often treated and prevented using the
pharmacological properties of traditional medicinal plants. These healthcare systems are …

Background Comorbid perennial allergic rhinitis (PAR) or year-round aeroallergen
sensitivity substantially contributes to disease burden in patients with asthma. Dupilumab …

After approximately 130 years since their discovery as rare granulocytes that circulate in
blood, basophils are just now gaining respect as significant contributors in the pathogenesis …

Background This paper reviews the current evidence indicating that comorbid allergic
rhinitis may have clinically relevant effects on asthma. Discussion Allergic rhinitis is very …