During the last decade, experimental and clinical studies have demonstrated that isolated
acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and …

Patients with traumatic brain injury (TBI) frequently require invasive mechanical ventilation
and admission to an intensive care unit. Ventilation of patients with TBI poses unique clinical …

Background In COVID-19 patients with acute respiratory distress syndrome (ARDS), the
effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy …

Although there is growing interest in the use of brain tissue oxygenation as a resuscitative
endpoint, many of these therapies are based on physiologic principles with little robust …

Neuropatients often require invasive mechanical ventilation (MV). Ideal ventilator settings
and respiratory targets in neuro patients are unclear. Current knowledge suggests …

Patients with acute brain injury (ABI) often require the application of positive end-expiratory
pressure (PEEP) to optimize mechanical ventilation and systemic oxygenation. However, the …

Although direct data to guide mechanical ventilation in brain-injured patients is
accumulating, the current evidence base remains limited. Ventilatory considerations in this …

Acute respiratory distress syndrome (ARDS) has been associated with secondary acute
brain injury (ABI). However, there is sparse literature on the mechanism of lung-mediated …

Considering the COVID-19 pandemic where concomitant occurrence of ARDS and severe
acute brain injury (sABI) has increasingly coemerged, we synthesize existing data regarding …

Severe acute brain injury (SABI) accounts for up to 25% of individuals receiving mechanical
ventilation (MV). 1, 2 Yet, there are insufficient data to inform ventilatory targets in this …