By replacing the antigen-binding domain, the present inventors discovered novel
polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety …

5,624,821 A 5,648,260 A 6,025,165 A 6,143,297 A 6,805,869 B2 7,183,076 B2 7,659,384
B2 8,080,250 B1 8,263,073 B2 8,298,801 B2 8,398,956 B2 8,592,562 B2 8,871,912 B2 …

The present invention is directed toward the delivery of a toxic protein to pathogenic cells,
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …

US20090317456A1 - Use of oncolytic viruses and antiangiogenic agents in the treatment of
cancer - Google Patents US20090317456A1 - Use of oncolytic viruses and antiangiogenic …

5,223.409 A 6/1993 Ladner 288-23-6. 66TY. 5,270,163 A 12, 1993 Gold Hamachi et
al.,“Design and semisynthesis of spermine-sensitive 5,270,204 A 12, 1993 Vallee …

US9006407B2 - Therapeutic ribonucleases - Google Patents US9006407B2 - Therapeutic
ribonucleases - Google Patents Therapeutic ribonucleases Download PDF Info Publication …

The present invention is directed toward the delivery of a toxic protein to pathogenic cells,
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …

The present invention relates generally to conjugates of human ribonucleases and water-
soluble polymers, composi tions comprising the conjugates and methods of using the same …

Protein therapeutics in general may offer particular advantages as alternatives to small
molecules; however, effective protein drugs must have a balance of optimal properties that …

5,270,163 A 12, 1993 Gold t1OnS comprising the conjugates and metho is of using the
5,270,204 A 12, 1993 Vallee same. In particular, the present invention provides conjugates …