Cytotoxicity-inducing therapeutic agent
J Nezu, T Ishiguro, A Narita, A Sakamoto… - US Patent …, 2021 - Google Patents
By replacing the antigen-binding domain, the present inventors discovered novel
polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety …
polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety …
T cell-redirected antigen-binding molecule for cells having immunosuppression function
T Igawa, T Ishiguro, S Sakaguchi… - US Patent …, 2022 - Google Patents
5,624,821 A 5,648,260 A 6,025,165 A 6,143,297 A 6,805,869 B2 7,183,076 B2 7,659,384
B2 8,080,250 B1 8,263,073 B2 8,298,801 B2 8,398,956 B2 8,592,562 B2 8,871,912 B2 …
B2 8,080,250 B1 8,263,073 B2 8,298,801 B2 8,398,956 B2 8,592,562 B2 8,871,912 B2 …
Non-natural ribonuclease conjugates as cytotoxic agents
LE Strong, PA Leland, T Burke - US Patent 8,470,315, 2013 - Google Patents
The present invention is directed toward the delivery of a toxic protein to pathogenic cells,
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
Use of oncolytic viruses and antiangiogenic agents in the treatment of cancer
M Karrasch, A Mescheder - US Patent App. 12/445,019, 2009 - Google Patents
US20090317456A1 - Use of oncolytic viruses and antiangiogenic agents in the treatment of
cancer - Google Patents US20090317456A1 - Use of oncolytic viruses and antiangiogenic …
cancer - Google Patents US20090317456A1 - Use of oncolytic viruses and antiangiogenic …
Therapeutic ribonucleases
T Klink, J Kink, L Strong - US Patent 8,029,782, 2011 - Google Patents
5,223.409 A 6/1993 Ladner 288-23-6. 66TY. 5,270,163 A 12, 1993 Gold Hamachi et
al.,“Design and semisynthesis of spermine-sensitive 5,270,204 A 12, 1993 Vallee …
al.,“Design and semisynthesis of spermine-sensitive 5,270,204 A 12, 1993 Vallee …
Therapeutic ribonucleases
T Klink, J Kink, L Strong - US Patent 9,006,407, 2015 - Google Patents
US9006407B2 - Therapeutic ribonucleases - Google Patents US9006407B2 - Therapeutic
ribonucleases - Google Patents Therapeutic ribonucleases Download PDF Info Publication …
ribonucleases - Google Patents Therapeutic ribonucleases Download PDF Info Publication …
Non-natural ribonuclease conjugates as cytotoxic agents
LE Strong, PA Leland, T Burke - US Patent 8,697,065, 2014 - Google Patents
The present invention is directed toward the delivery of a toxic protein to pathogenic cells,
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
Modified ribonucleases
JA Kink, LE Strong, V Trubetskoy… - US Patent 8,840,882, 2014 - Google Patents
The present invention relates generally to conjugates of human ribonucleases and water-
soluble polymers, composi tions comprising the conjugates and methods of using the same …
soluble polymers, composi tions comprising the conjugates and methods of using the same …
Therapeutic ribonucleases
T Klink, J Kink, L Strong - US Patent 8,216,567, 2012 - Google Patents
Protein therapeutics in general may offer particular advantages as alternatives to small
molecules; however, effective protein drugs must have a balance of optimal properties that …
molecules; however, effective protein drugs must have a balance of optimal properties that …
Compositions and methods for ribonuclease-based therapeutics
RT Raines, TJ Rutkoski, JA Kink, LE Strong - US Patent 8,697,062, 2014 - Google Patents
5,270,163 A 12, 1993 Gold t1OnS comprising the conjugates and metho is of using the
5,270,204 A 12, 1993 Vallee same. In particular, the present invention provides conjugates …
5,270,204 A 12, 1993 Vallee same. In particular, the present invention provides conjugates …