Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or
hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors …

The immune system is affected by the aging process and undergoes significant age-related
changes, termed immunosenescence. Different T cell subsets are affected by this process …

Virus-specific CD8+ T-cell responses play a pivotal role in limiting viral replication.
Alterations in these responses, such as decreased cytolytic function, inappropriate …

Viral infections induce extensive T cell proliferation in vivo, but the specificity of the majority
of the responding T cells has not been defined. To address this issue we used tetramers of …

To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1)
disease, long-and short-duration survivors were studied after their CD4+ T cells fell to⩽ …

A unique cohort of HIV-1-infected long term nonprogressors (LTNP) with normal CD4+ T cell
counts and< 50 copies/ml of plasma were prospectively recruited for study. HLA typing …

The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV)
infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in …

To evaluate the impact of sustained viral loads on anti-viral T cell responses we compared
responses that cleared acute lymphocytic choriomeningitis virus infection with those that …

1BB (CD137) is a costimulatory molecule expressed on activated T cells and interacts with 4-
1BB ligand (4-1BBL) on APCs. To investigate the role of 4-1BB costimulation for the …

In HIV-1–infected patients, increased numbers of circulating CD8+ T cells are linked to
increased risk of morbidity and mortality. Here, we identified a bystander mechanism that …