Thermal immuno-nanomedicine in cancer

Z Yang, D Gao, J Zhao, G Yang, M Guo… - Nature Reviews …, 2023 - nature.com
Immunotherapy has revolutionized the treatment of patients with cancer. However,
promoting antitumour immunity in patients with tumours that are resistant to these therapies …

[HTML][HTML] Roles of CD4+ T cells as mediators of antitumor immunity

DS Kravtsov, AK Erbe, PM Sondel… - Frontiers in …, 2022 - frontiersin.org
It has been well established that CD8+ T cells serve as effector cells of the adaptive immune
response against tumors, whereas CD4+ T cells either help or suppress the generation of …

[HTML][HTML] In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy

W Ou, S Stewart, A White, EA Kwizera, J Xu… - Nature …, 2023 - nature.com
Cancer immunotherapy that deploys the host's immune system to recognize and attack
tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted …

Liquid metal microparticles phase change medicated mechanical destruction for enhanced tumor cryoablation and dual‐mode imaging

X Sun, B Cui, B Yuan, X Wang, L Fan… - Advanced Functional …, 2020 - Wiley Online Library
Mechanical forces are crucial for normal living organisms as well as formation of tumor
microenvironments. However, to date, there are rather limited trials to regulate the …

[HTML][HTML] Hyperthermia targeting the tumor microenvironment facilitates immune checkpoint inhibitors

Z Li, J Deng, J Sun, Y Ma - Frontiers in Immunology, 2020 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have ushered in a new era of cancer therapy; however,
ICIs are only effective in selective patients. The efficacy of ICIs is closely related to the tumor …

[HTML][HTML] Microwave ablation induces Th1-type immune response with activation of ICOS pathway in early-stage breast cancer

W Zhou, M Yu, H Pan, W Qiu, H Wang… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Despite great advances in the treatment of breast cancer, innovative
approaches are still needed to reduce metastasis. As a minimally invasive local therapy (not …

[HTML][HTML] Immunomodulatory effect of locoregional therapy in the tumor microenvironment

L Xie, Z Meng - Molecular Therapy, 2023 - cell.com
Cancer immunotherapy appears to be a promising treatment option; however, only a subset
of patients with cancer responds favorably to treatment. Locoregional therapy initiates a …

Programmed Upregulation of HSP70 by Metal‐Organic Frameworks Nanoamplifier for Enhanced Microwave Thermal‐Immunotherapy

W Guo, M Niu, Z Chen, Q Wu, L Tan… - Advanced …, 2022 - Wiley Online Library
Thermotherapy can directly kill tumor cells whilst being accompanied by immune‐enhancing
effects. However, this immune‐enhancing effect suffers from insufficient expression of …

[HTML][HTML] Amplifying cancer treatment: advances in tumor immunotherapy and nanoparticle-based hyperthermia

Y Zhang, Z Li, Y Huang, B Zou, Y Xu - Frontiers in Immunology, 2023 - frontiersin.org
In the quest for cancer treatment modalities with greater effectiveness, the combination of
tumor immunotherapy and nanoparticle-based hyperthermia has emerged as a promising …

[HTML][HTML] Immunotherapeutic potential of T memory stem cells

Y Li, D Wu, X Yang, S Zhou - Frontiers in oncology, 2021 - frontiersin.org
Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM).
Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better …