Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …

Alzheimer's disease's pathophysiology is still a conundrum. Growing number of evidences
have elucidated the involvement of oxidative stress in the pathology of AD rendering it a …

Alzheimer's disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder.
As the exact cause of the disease is still unclear, the drug development is very challenging …

Alzheimer's disease is a leading cause of mortality worldwide. Inorganic and organic
hazards, susceptibility to harmful metals, pesticides, agrochemicals, and air pollution are …

ABSTRACT Introduction: Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron
progressive disorder for which no treatment exists to date. However, there are other …

A 55–200 CGG repeat expansion in the 5′-UTR of the fragile X mental retardation 1
(FMR1) gene is known as a premutation. Some carriers are affected by the …

This study represents an analysis of the thermal aggregation of human serum albumin
(HSA) induced by novel rosin modified compounds. The aggregation process causes …

P2X7 is an adenosine 5'-triphosphate (ATP)-gated ion channel that plays many roles in
health and disease. P2X7 is present on various cell types, including most immune cells, and …

Amyotrophic lateral sclerosis (ALS) is a complex, progressive and fatal motor neuron
disease. There are currently no effective treatments for ALS. P2X7 receptor is a ligand-gated …

This thesis investigated the effects of pharmacological and non-pharmacological therapeutic
approaches on skeletal muscle health and disease progression in a novel mouse model …