Clinical applications of stem cell-derived exosomes

F Tan, X Li, Z Wang, J Li, K Shahzad… - Signal Transduction and …, 2024 - nature.com
Although stem cell-based therapy has demonstrated considerable potential to manage
certain diseases more successfully than conventional surgery, it nevertheless comes with …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Engineered extracellular vesicles with SHP2 high expression promote mitophagy for Alzheimer's disease treatment

F Xu, Y Wu, Q Yang, Y Cheng, J Xu, Y Zhang… - Advanced …, 2022 - Wiley Online Library
Mitochondrial dysfunction is a fundamental pathological feature of Alzheimer's disease (AD).
However, toxicity and poor brain enrichment of existing mitophagy inducers limit their further …

Extracellular vesicles: Emerging frontiers in wound healing

MD Hade, CN Suire, J Mossell… - Medicinal Research …, 2022 - Wiley Online Library
Extracellular vesicles are membranous particles, ranging from 30 nm to 10 µm in diameter,
which are released by nearly all cell types to aid in intercellular communication. These …

[HTML][HTML] Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment

Q Yi, Z Xu, A Thakur, K Zhang, Q Liang, Y Liu… - Pharmacological …, 2023 - Elsevier
Natural compounds are widely used to prevent and treat various diseases due to their
antioxidant and anti-inflammatory effects. As a kind of promising natural compound, plant …

[HTML][HTML] Engineering strategies and optimized delivery of exosomes for theranostic application in nerve tissue

Q Li, X Fu, Y Kou, N Han - Theranostics, 2023 - ncbi.nlm.nih.gov
Severe injuries or diseases affecting the peripheral and central nervous systems can result
in impaired organ function and permanent paralysis. Conventional interventions, such as …

Unwinding circular RNA's role in inflammatory pulmonary diseases

AA Bhat, G Gupta, A Goyal, R Thapa… - Naunyn-Schmiedeberg's …, 2024 - Springer
Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression and
cellular processes in various physiological and pathological conditions. In recent years …

[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers

S Liu, X Wu, S Chandra, C Lyon, B Ning, J Fan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …

Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury

L Zhong, J Wang, P Wang, X Liu, P Liu… - Stem Cell Research & …, 2023 - Springer
Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive
clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior …

An effective peptide-based platform for efficient exosomal loading and cellular delivery of a microRNA

MD Hade, CN Suire, Z Suo - ACS Applied Materials & Interfaces, 2023 - ACS Publications
Exosomes, membrane-bound nanosized vesicles of biologic origin, are known to contain
various molecules, eg, proteins, lipids, and nucleic acids, which contribute to the exosomes' …