Current status of angiogenic cell therapy and related strategies applied in critical limb ischemia

L Beltrán-Camacho, M Rojas-Torres… - International Journal of …, 2021 - mdpi.com
Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …

Therapeutic Lymphangiogenesis is a promising strategy for secondary lymphedema

Y Shimizu, Y Che, T Murohara - International journal of molecular …, 2023 - mdpi.com
Secondary lymphedema is caused by lymphatic insufficiency (lymphatic drainage failure)
following lymph node dissection during the surgical treatment or radiation therapy of breast …

Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial

Y Shimizu, K Kondo, R Hayashida, K Sasaki… - Angiogenesis, 2022 - Springer
Background Patients with critical limb ischemia (CLI) still have a high rate of lower limb
amputation, which is associated with not only a decrease in quality of life but also poor life …

Image-based crosstalk analysis of cell–cell interactions during sprouting angiogenesis using blood-vessel-on-a-chip

T Sano, T Nakajima, KA Senda, S Nakano… - Stem Cell Research & …, 2022 - Springer
Background Sprouting angiogenesis is an important mechanism for morphogenetic
phenomena, including organ development, wound healing, and tissue regeneration. In …

From primary MSC culture of adipose tissue to immortalized cell line producing cytokines for potential use in regenerative medicine therapy or immunotherapy

M Paprocka, H Kraskiewicz, A Bielawska-Pohl… - International Journal of …, 2021 - mdpi.com
For twenty-five years, attempts have been made to use MSCs in the treatment of various
diseases due to their regenerative and immunomodulatory properties. However, the results …

Angiogenesis in diabetic mouse model with critical limb ischemia; cell and gene therapy

SL Asadi-Yousefabad, P Nammian, SMB Tabei… - Microvascular …, 2022 - Elsevier
Purpose Critical limb ischemia (CLI) is the most severe manifestation of peripheral artery
disease that diabetes mellitus is one of its major risk factors. MiR-126 as an endothelial cells …

[HTML][HTML] Zinc deficiency impairs ischemia-induced angiogenesis

T Tsuruoka, A Kodama, S Yamaguchi, T Masutomi… - JVS-Vascular …, 2022 - Elsevier
Objective Zinc is an important essential trace metal involved in many physiologic functions,
and its deficiency can affect the development of multiple organs, including the vasculature …

基质细胞衍生因子1α 诱导脂肪来源干细胞迁移促进糖尿病缺血下肢肌肉修复的实验研究

黄东琳, 梁至洁, 朱丹丹, 蒋洪棉, 宁艳, 黎洪棉 - 中国普通外科杂志, 2023 - zpwz.net
摘要背景与目的: 基质细胞衍生因子1α (SDF-1α) 是一种定向诱导细胞迁移的趋化因子,
研究显示, 间充质干细胞(MSCs) 在受损组织中可以沿着SDF-1 梯度迁移到损伤部位并参与组织 …

Important role of concomitant lymphangiogenesis for reparative angiogenesis in hindlimb ischemia

Z Pu, Y Shimizu, K Tsuzuki, J Suzuki… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Lymphatic vessels are distributed throughout the body and tightly collaborate with
blood vessels to maintain tissue homeostasis. However, the functional roles of …

Modalities to Deliver Cell Therapy for Treatment of Chronic Limb Threatening Ischemia

O Setia, SR Lee, A Dardik - Advances in Wound Care, 2024 - liebertpub.com
Significance: Chronic limb threatening ischemia (CLTI) is a severe form of peripheral arterial
disease (PAD) that is associated with high rates of morbidity and mortality, and especially …