Recent advancements in electroporation technologies: from bench to clinic

SN Campelo, PH Huang, CR Buie… - Annual Review of …, 2023 - annualreviews.org
Over the past decade, the increased adoption of electroporation-based technologies has led
to an expansion of clinical research initiatives. Electroporation has been utilized in …

Research progress of nucleic acid detection technology for genetically modified maize

T Luo, L Li, S Wang, N Cheng - International Journal of Molecular …, 2023 - mdpi.com
Genetically modified (GM) maize is one of the earliest GM crops to have achieved large-
scale commercial cultivation globally, and it is of great significance to excel in the …

Engineering Efficient CAR‐T Cells via Electroactive Nanoinjection

AR Shokouhi, Y Chen, HZ Yoh, J Brenker… - Advanced …, 2023 - Wiley Online Library
Chimeric antigen receptor (CAR)‐T cell therapy has emerged as a promising cell‐based
immunotherapy approach for treating blood disorders and cancers, but genetically …

Systemic tumor suppression via macrophage‐driven automated homing of metal‐phenolic‐gated nanosponges for metastatic melanoma

X Liao, G Gong, M Dai, Z Xiang, J Pan, X He… - Advanced …, 2023 - Wiley Online Library
Cell‐based therapies comprising the administration of living cells to patients for direct
therapeutic activities have experienced remarkable success in the clinic, of which …

Electroactive nanoinjection platform for intracellular delivery and gene silencing

AR Shokouhi, Y Chen, HZ Yoh, T Murayama… - Journal of …, 2023 - Springer
Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

Integrated cardiomyocyte-based biosensing platform for electroporation-triggered intracellular recording in parallel with delivery efficiency evaluation

J Fang, Y Pan, J Xu, D Xu, H Li, C Liu, N Hu - Nano Letters, 2023 - ACS Publications
Electroporation is a proven technique that can record action potential of cardiomyocytes and
serve for biomolecular delivery. To ensure high cell viability, micro-nanodevices cooperating …

Self‐Powered Electrically Controlled Drug Release Systems Based on Nanogenerator

W Luo, R Luo, J Liu, Z Li, Y Wang - Advanced Functional …, 2024 - Wiley Online Library
Precision medicine requires precise regulation of drugs in terms of time, space, and dosage.
Exogenous control systems, such as electrical responsiveness, have made great progress …

Engineered extracellular vesicles as therapeutics of degenerative orthopedic diseases

J Wei, Z Ou, B Tong, Z Liao, C Yang - Frontiers in bioengineering and …, 2023 - frontiersin.org
Degenerative orthopedic diseases, as a global public health problem, have made serious
negative impact on patients' quality of life and socio-economic burden. Traditional …

Ultrasonic Electroporation for Cells Grown on Piezoelectric Film Composed of Hydroxyapatite Nanowire and PVDF

J Dolai, AR Sarkar, A Maity, B Mukherjee… - ACS Applied Materials …, 2023 - ACS Publications
The delivery of cell impermeable exogenous material into live cells by external stimuli is
critical for both biological research and therapeutic applications. Although electroporation …

Artificial Breakthrough of Cell Membrane Barrier for Transmembrane Substance Exchange: A Review of Recent Progress

L Wang, X Zhu, C Xu, D Jin, X Ma - Advanced Functional …, 2024 - Wiley Online Library
Cell membrane composed of lipid bilayer is a selectively permeable membrane that only
allows specific molecules to pass through. While such selectivity is essential for the survival …