Genetics and intelligence differences: five special findings
Intelligence is a core construct in differential psychology and behavioural genetics, and
should be so in cognitive neuroscience. It is one of the best predictors of important life …
should be so in cognitive neuroscience. It is one of the best predictors of important life …
[HTML][HTML] Narrative review of intellectual disability: definitions, evaluation and principles of treatment
DR Patel, R Apple, S Kanungo, A Akkal - Pediatric Medicine, 2018 - pm.amegroups.org
Methods: We conducted a literature search (2005-2020) using online database PubMed,
specifically for studies related to the clinical aspects of intellectual disability as they apply to …
specifically for studies related to the clinical aspects of intellectual disability as they apply to …
Exome sequencing and the management of neurometabolic disorders
M Tarailo-Graovac, C Shyr, CJ Ross… - … England Journal of …, 2016 - Mass Medical Soc
Background Whole-exome sequencing has transformed gene discovery and diagnosis in
rare diseases. Translation into disease-modifying treatments is challenging, particularly for …
rare diseases. Translation into disease-modifying treatments is challenging, particularly for …
Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior
Haploinsufficiency of the AT-rich interactive domain 1B (ARID1B) gene causes autism
spectrum disorder and intellectual disability; however, the neurobiological basis for this is …
spectrum disorder and intellectual disability; however, the neurobiological basis for this is …
XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing
Because of the unbalanced sex ratio (1.3–1.4 to 1) observed in intellectual disability (ID) and
the identification of large ID-affected families showing X-linked segregation, much attention …
the identification of large ID-affected families showing X-linked segregation, much attention …
Discontinuity in the genetic and environmental causes of the intellectual disability spectrum
A Reichenberg, M Cederlöf… - Proceedings of the …, 2016 - National Acad Sciences
Intellectual disability (ID) occurs in almost 3% of newborns. Despite substantial research, a
fundamental question about its origin and links to intelligence (IQ) still remains. ID has been …
fundamental question about its origin and links to intelligence (IQ) still remains. ID has been …
Genetics of recessive cognitive disorders
L Musante, HH Ropers - Trends in Genetics, 2014 - cell.com
Most severe forms of intellectual disability (ID) have specific genetic causes. Numerous X
chromosome gene defects and disease-causing copy-number variants have been linked to …
chromosome gene defects and disease-causing copy-number variants have been linked to …
Next-generation sequencing in X-linked intellectual disability
A Tzschach, U Grasshoff, S Beck-Woedl… - European Journal of …, 2015 - nature.com
X-linked intellectual disability (XLID) is a genetically heterogeneous disorder with more than
100 genes known to date. Most genes are responsible for a small proportion of patients only …
100 genes known to date. Most genes are responsible for a small proportion of patients only …
Developmental perspectives on the study of persons with intellectual disability
Developmental approaches provide inclusive, universal, and methodologically rigorous
frameworks for studying persons with intellectual disability (ID). This is an exceptionally …
frameworks for studying persons with intellectual disability (ID). This is an exceptionally …
tRNA metabolism and neurodevelopmental disorders
AE Schaffer, O Pinkard, JM Coller - Annual review of genomics …, 2019 - annualreviews.org
tRNAs are short noncoding RNAs required for protein translation. The human genome
includes more than 600 putative tRNA genes, many of which are considered redundant …
includes more than 600 putative tRNA genes, many of which are considered redundant …