An atypical ABC transporter is involved in antifungal resistance and host interactions in the pathogenic fungus Cryptococcus neoformans

CJ Winski, Y Qian, S Mobashery, FH Santiago-Tirado - Mbio, 2022 - Am Soc Microbiol
ABSTRACT ATP-binding cassette (ABC) transporters represent one of the largest protein
superfamilies. Functionally diverse, ABC transporters have been implicated in many aspects …

[HTML][HTML] Analyses of the Global Multilocus Genotypes of the Human Pathogenic Yeast Cryptococcus neoformans Species Complex

M Hitchcock, J Xu - Genes, 2022 - mdpi.com
Cryptococcus neoformans species complex (CNSC) is a globally distributed human
opportunistic yeast pathogen consisting of five major molecular types (VNI, VNII, VNB, VNIII …

[HTML][HTML] Molecular Epidemiology and Antifungal Resistance of Cryptococcus neoformans From Human Immunodeficiency Virus-Negative and Human …

Z Zhou, C Zhu, M Ip, M Liu, Z Zhu, R Liu, X Li… - Frontiers in …, 2022 - frontiersin.org
Cryptococcosis is an opportunistic and potentially lethal infection caused by Cryptococcus
neoformans and Cryptococcus gattii complex, which affects both immunocompromised and …

[HTML][HTML] Analysis of the relationship between drug susceptibility of Cryptococcus neoformans isolates and mortality in HIV-negative cryptococcal meningitis

Z Su, H Wei, J Liu, C Li, Z Xu, D Yuan, K Dai… - Journal of Global …, 2024 - Elsevier
Objectives The relationship between antifungal susceptibility and mortality of cryptococcal
meningitis (CM) in HIV-negative patients is poorly understood. Methods We conducted a …

[HTML][HTML] Epidemiological and Clinical Characteristics, Antifungal Susceptibility, and MLST-Based Genetic Analysis of Cryptococcus Isolates in Southern Taiwan in …

YC Chen, SF Kuo, SY Lin, YS Lin, CH Lee - Journal of Fungi, 2022 - mdpi.com
Cryptococcal meningoencephalitis (CM) is a treatable condition, but it leads to excessive
morbidity and mortality. We collected 115 non-duplicated Cryptococcus clinical isolates …

[HTML][HTML] Design of a cryptococcus neoformans vaccine by subtractive proteomics combined with immunoinformatics

F Zhu, Z Zhou, S Ma, Y Xu, C Tan, H Yang… - International …, 2024 - Elsevier
The emergence of Cryptococcus neoformans has posed an undeniable burden to many
regions worldwide, with its strains mainly entering the lungs through the respiratory tract and …

Involvement of the Noncanonical Polyadenylation Polymerase Cid14 in Fungal Azole Resistance in the Pathogen Cryptococcus neoformans

C Li, S Zhen, X Ma, L Ma, Z Wang… - Pathogens and …, 2022 - academic.oup.com
The yeast noncanonical polyadenylation polymerase Cid14 was originally identified from
fission yeast and plays a critical role in the TRAMP complex. This protein is a cytoplasmic …

Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans species complex from China, including the diploid VNIII isolates from HIV-infected …

L Zhang, S Wang, N Hong, M Li, Y Liu, T Zhou… - Medical …, 2023 - academic.oup.com
Although previous studies on the genotypic diversity and antifungal susceptibility of the
Cryptococcus neoformans species complex (CNSC) isolates from China revealed ST5 …

Induction therapy with high‐dose fluconazole plus flucytosine for human immunodeficiency virus‐uninfected cryptococcal meningitis patients: Feasible or not?

HZ Zhao, JH Cheng, LH Zhou, Y Luo, RS Zhu… - Mycoses, 2023 - Wiley Online Library
Background Cryptococcal meningitis (CM) is increasingly recognised in human
immunodeficiency virus (HIV)‐uninfected patients with high mortality. The efficacy and safety …

Micosis en pacientes inmunocomprometidos

JMO Gutiérrez - Medicine-Programa de Formación Médica Continuada …, 2022 - Elsevier
Con el incremento de personas inmunosuprimidas crece la susceptibilidad a presentar
infecciones, entre ellas las infecciones fúngicas invasoras. Este cambio en la epidemiología …