Rodent models of glaucoma

TV Johnson, SI Tomarev - Brain research bulletin, 2010 - Elsevier
Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible
blindness in the world. Animal models of glaucoma are essential to our continued efforts of …

Clinical potential of adrenomedullin signaling in the cardiovascular system

L Bálint, NP Nelson-Maney, Y Tian, SD Serafin… - Circulation …, 2023 - Am Heart Assoc
Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-
proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a …

Rodent genetically modified models of glaucoma

Y Loo, ASY Chan, CC Khor, T Aung, Z Wang - Molecular Aspects of …, 2024 - Elsevier
Glaucoma, one of the leading causes of irreversible blindness worldwide, is a complex and
heterogenous disease. While environmental factors are important, it is well-recognized that …

Updates on genes and genetic mechanisms implicated in primary angle-closure glaucoma

AA Kondkar - The application of clinical genetics, 2021 - Taylor & Francis
Primary angle-closure glaucoma (PACG) is estimated to affect over 30 million people
worldwide by 2040 and is highly prevalent in the Asian population. PACG is more severe …

Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice

SL Hoopes, HH Willcockson, KM Caron - 2012 - journals.plos.org
Adrenomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl)
and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial …

Calcitonin gene-related peptide (CGRP) receptors are important to maintain cerebrovascular reactivity in chronic hypertension

Z Wang, BC Martorell, T Wälchli, O Vogel, J Fischer… - PloS one, 2015 - journals.plos.org
Cerebral blood flow autoregulation (CA) shifts to higher blood pressures in chronic
hypertensive patients, which increases their risk for brain damage. Although cerebral …

[HTML][HTML] Genetic susceptibility to primary angle closure glaucoma (PACG)

BS Shastry - Discovery medicine, 2013 - discoverymedicine.com
Glaucoma is a group of heterogeneous optic neuropathy and is the second leading cause of
irreversible blindness worldwide. The two most common clinical types of glaucoma include …

In vivo OCT microangiography of rodent iris

WJ Choi, Z Zhi, RK Wang - Optics letters, 2014 - opg.optica.org
We report on the functional optical coherence tomography (OCT) imaging of iris tissue
morphology and microcirculation in living small animals. Anterior segments of healthy …

The rodent model of glaucoma and its implications

S Chen, X Zhang - The Asia-Pacific journal of ophthalmology, 2015 - journals.lww.com
Glaucoma is a group of progressive optic neuropathies, characterized by the degeneration
of retinal ganglion cells related to the level of intraocular pressure and other factors. The …

[HTML][HTML] Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma

D Cao, X Liu, X Guo, Y Cong, J Huang, Z Mao - Molecular vision, 2009 - ncbi.nlm.nih.gov
Purpose To determine whether the polymorphisms of calcitonin receptor-like receptor gene
(CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern …