Purpose: Thyroid cancer cell lines are valuable models but have been neglected in
pancancer genomic studies. Moreover, their misidentification has been a significant …

The molecular profiling of tumour samples is elucidating the genetic alterations involved in
ATC development, and new preclinical models are under study to define innovative …

Due to a global increase in the incidence of thyroid cancer, numerous novel mouse models
were established to reveal thyroid cancer pathogenesis and test promising therapeutic …

The earliest mammalian cell lines, established by Earle et al. in 1943, were derived from the
subcutaneous tissue of a C3H mouse strain and many cell lines still used today were …

The pentose phosphate pathway (PPP) plays an important role in the biosynthesis of
ribonucleotide precursor and NADPH. Cancer cells frequently increase the flux of glucose …

Background Of the half a million cases of thyroid cancer diagnosed annually, 95% are
differentiated thyroid cancers. Although clinical guidelines recommend surgical resection …

Thyroid cancer is one of the most common endocrine malignancies. Although the prognosis
for the majority of thyroid cancers is relatively good, patients with metastatic, radioiodine …

Context Anaplastic thyroid cancer (ATC) is a rare, aggressive, and deadly disease. Robust
preclinical thyroid cancer models are needed to adequately develop and study novel …

Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive malignancy with
poor outcomes. To investigate novel therapeutic strategies, we characterized three new …

Cancer cell lines are critical models to study tumor progression and response to therapy. In
2008, we showed that approximately 50% of thyroid cancer cell lines were redundant or not …