Hypertension is an important risk factor for cardiovascular morbidity and mortality and for
events such as myocardial infarction, stroke, heart failure and chronic kidney disease and is …

Long-term elevated blood pressure will increase the cardiac load and lead to myocardial
fibrosis (MF). A variety of pathological mechanisms and signal transduction pathways are …

Background Cancer patients receiving anthracycline-based chemotherapy (Anth-bC) may
experience early cardiac fibrosis, which could be an important contributing mechanism to …

Endometriotic lesions are known to be hyperinnervated, especially in lesions of deep
endometriosis (DE), which are frequently in close proximity to various nerve plexuses. DE …

Rationale: DPP-4 (dipeptidyl peptidase-4) inhibitors have increased the risk of heart failure
events in both randomized clinical trials and observational studies, but the mechanisms that …

Dipeptidyl peptidase-4 (DPP-4) is an important protease that is widely expressed on the
surface of human cells and plays a key role in immune-regulation, inflammation, oxidative …

Diabetic patients have a two-to four-fold increase in the risk of heart failure (HF), and the co-
existence of diabetes and HF is associated with poor prognosis. In randomized clinical trials …

Historically, increased numbers of mast cells have been associated with fibrosis in
numerous cardiac pathologies, implicating mast cells in the development of cardiac fibrosis …

Reduced levels of the sensory nerve neuropeptide substance P (SP) have been reported in
the diabetic rat heart, the consequence being a loss of cardioprotection in response to …

Abstract Novel Coronavirus infection (COVID-19) has become a pandemic in these days. It
is an acute respiratory and infectious disease with no known etiology and treatment. It is …