The morbidity and mortality caused by invasive fungal infections are increasing across the
globe due to developments in transplant surgery, the use of immunosuppressive agents …

G-protein coupled receptor (GPCR) mediated calcium (Ca 2+)-signaling transduction
remains crucial in designing drugs for various complex diseases including …

Excess of histamine in gut lumen generates a pronounced gastrointestinal discomfort, which
may include diarrhea and peristalsis dysfunctions. Deleterious effects of histamine can be …

Abstract Live cell calcium (Ca2+) imaging is one of the important tools to record cellular
activity during in vitro and in vivo preclinical studies. Specially, high-resolution microscopy …

Renal fibrosis arises by the generation of matrix-producing fibroblasts and myofibroblasts
through the epithelial–mesenchymal transition (EMT), a process in which epithelial cells …

The development of induced-pluripotent stem cell (iPSC)-derived cell types offers promise
for basic science, drug testing, disease modeling, personalized medicine, and translatable …

Gallstone disease is a worldwide common disease. However, the knowledge concerning the
gallbladder in the pathogenesis of cholesterol gallstone formation remains limited. In this …

Cell extravasation is a crucial step of the metastatic cascade. In this process, the circulating
tumor cells inside the blood vessels adhere to the cell monolayer of the blood vessel wall …

Osteoblasts in multicellular organisms are sensitive to fluid shear stress (Fss) and respond
smartly with versatile patterns of intracellular calcium signal ([Ca 2+] i). In this study, a spatial …

Understanding how the mechanical microenvironment affects cardiomyocyte development is
crucial to the creation of in vitro models for studying heart physiology and pathophysiology …