Delivering on the promise of recombinant silk-inspired proteins for drug delivery

C Gonzalez-Obeso, EJ Hartzell, RA Scheel… - Advanced drug delivery …, 2023 - Elsevier
Effective drug delivery is essential for the success of a medical treatment. Polymeric drug
delivery systems (DDSs) are preferred over systemic administration of drugs due to their …

CRISPR/Cas9 in lepidopteran insects: Progress, application and prospects

JJ Li, Y Shi, JN Wu, H Li, G Smagghe, TX Liu - Journal of insect physiology, 2021 - Elsevier
Clustered regularly spaced short palindrome repeats (CRISPR) structure family forms the
acquired immune system in bacteria and archaea. Recent advances in CRISPR/Cas …

Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

H Liu, J Xu, L Wang, P Guo, Z Tang, X Sun… - PLoS …, 2023 - journals.plos.org
The Toll receptor signaling pathway is an important innate immune response of insects to
pathogen infection; its extracellular signal transduction involves serine protease cascade …

SilkMeta: a comprehensive platform for sharing and exploiting pan-genomic and multi-omic silkworm data

K Lu, Y Pan, J Shen, L Yang, C Zhan… - Nucleic Acids …, 2024 - academic.oup.com
The silkworm Bombyx mori is a domesticated insect that serves as an animal model for
research and agriculture. The silkworm super-pan-genome dataset, which we published last …

[HTML][HTML] Combined analysis of silk synthesis and hemolymph amino acid metabolism reveal key roles for glycine in increasing silkworm silk yields

X Chen, A Ye, X Wu, Z Qu, S Xu, Y Sima… - International Journal of …, 2022 - Elsevier
Rearing silkworms (Bombyx mori) using formula feed has revolutionized traditional mulberry
feed strategies. However, low silk production efficiencies persist and have caused …

BmPMFBP1 regulates the development of eupyrene sperm in the silkworm, Bombyx mori

D Yang, J Xu, K Chen, Y Liu, X Yang, L Tang… - PLoS …, 2022 - journals.plos.org
Sperm deliver the male complement of DNA to the ovum, and thus play a key role in sexual
reproduction. Accordingly, spermatogenesis has outstanding significance in fields as …

Advances in Editing Silkworms (Bombyx mori) Genome by Using the CRISPR-Cas System

GM Baci, AA Cucu, AI Giurgiu, AS Muscă, L Bagameri… - Insects, 2021 - mdpi.com
Simple Summary One of the most powerful gene editing approaches is the CRISPR
(clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) tool …

From phyllosphere to insect cuticles: silkworms gather antifungal bacteria from mulberry leaves to battle fungal parasite attacks

P Zhao, S Hong, Y Li, H Chen, H Gao, C Wang - Microbiome, 2024 - Springer
Background Bacterial transfers from plants to insect herbivore guts have been well
investigated. However, bacterial exchanges between plant phyllospheres and insect cuticles …

High-throughput and genome-scale targeted mutagenesis using CRISPR in a nonmodel multicellular organism, Bombyx mori

S Ma, T Zhang, R Wang, P Wang, Y Liu… - Genome …, 2024 - genome.cshlp.org
Large-scale genetic mutant libraries are powerful approaches to interrogating genotype–
phenotype correlations and identifying genes responsible for certain environmental stimuli …

BmSPP is a virus resistance gene in Bombyx mori

Y Feng, C Yang, L Wu, Y Wang, G Shen… - Frontiers in …, 2024 - frontiersin.org
Introduction Signal peptide peptidase (SPP) is an intramembrane protease involved in a
variety of biological processes, it participates in the processing of signal peptides after the …