Superoxide is a primary oxygen radical that is produced when an oxygen molecule receives
one electron. Superoxide dismutase (SOD) plays a primary role in the cellular defense …

Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in
eukaryotes and viruses. They can function by regulating target gene expression, linear RNA …

NRF2 (nuclear factor erythroid 2-related factor 2) is a critical regulator of the cellular stress
response. It is a transcription factor that controls the expression of hundreds of genes. We …

Background Increasing evidence shows that circular RNAs (circRNAs), a novel class of
noncoding RNAs, play a crucial role in the development of cancers, including intrahepatic …

Peroxiredoxins are multifunctional enzymes that play a key role in protecting cells from
stresses and maintaining the homeostasis of many cellular processes. Peroxiredoxins were …

Sarcopenia, the age-related decline in muscle mass and function, derives from multiple
etiological mechanisms. Accumulative research suggests that reactive oxygen species …

Objectives This review summarises the current findings regarding the therapeutic effects of
GBE and its active ingredients in relation to the Nrf2 antioxidant cascade, to provide …

Abstract Thioredoxin reductase 1 (TXNRD1) is one of the major redox regulators in
mammalian cells, which has been reported to be involved in tumorigenesis. However, its …

Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate
cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In …

Significance: KRIT1 (Krev interaction trapped 1) is a scaffolding protein that plays a critical
role in vascular morphogenesis and homeostasis. Its loss-of-function has been …