Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in
mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the …

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

Abstract The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs)
enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that …

Ovulation is the appropriately timed release of a mature, developmentally competent oocyte
from the ovary into the oviduct, where fertilization occurs. Importantly, ovulation is tightly …

The major goal of this review is to summarize recent exciting findings that have been
published within the past 10 years that, to our knowledge, have not been presented in detail …

Cumulus cell–oocyte communication is an essential feature of mammalian reproduction.
Established mechanisms involve the bidirectional transfer of ions and small molecules …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Mammalian reproduction hinges upon the timely ovulation of a fully differentiated oocyte.
This event is the culmination of a complex and dynamic developmental relationship between …

The central role of luteinizing hormone (LH) and its receptor (LHCGR) in triggering ovulation
has been recognized for decades. Because the LHCGR is present in the mural (outermost) …

The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7
ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant …