The first classification on this topic categorized cardiomyopathies as heart muscle diseases
with dilated (DCM), hypertrophic, restrictive, arrhythmogenic right ventricular (ARVC), or …

Remarkable progress has been made in understanding the genetic basis of dilated
cardiomyopathy (DCM). Rare variants in> 30 genes, some also involved in other …

A great deal of progress has recently been made in the discovery and understanding of the
genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a …

Cardiomyopathies (ie, diseases of the heart muscle) are major causes of morbidity and
mortality. A significant percentage of patients with cardiomyopathies have genetic-based …

Left ventricular noncompaction (LVNC), characterized by excessive and unusual
trabeculation of the mature left ventricle (LV), has been considered to be a developmental …

Background—Today, mutations in more than 30 different genes have been found to cause
inherited cardiomyopathies, some associated with very poor prognosis. However, because …

The SCN5A gene encodes the alpha-subunit of the Na v 1.5 ion channel protein, which is
responsible for the sodium inward current (I Na). Since 1995 several hundred mutations in …

AIMS We identified an autosomal dominant non-sense mutation (R225X) in exon 4 of the
lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated …

Objectives: The goal of this study was to characterize a variant in the SCN5A gene that
encodes the alpha-subunit of the cardiac sodium channel, Nav1. 5, which was identified in 1 …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure. In families with autosomal-
dominant DCM, heterozygous missense mutations were identified in RNA-binding motif …