Inherited gene variants have been implicated increasingly in cardiac disorders but the
clinical impact of these discoveries has been variable. For some disorders, such as familial …

Atrial fibrillation (AF) often complicates the course of inherited cardiomyopathies and, in
some cases, may be the presenting feature. Each inherited cardiomyopathy has its own …

Rationale: Mutations in the LMNA gene, which encodes the nuclear lamina proteins lamin A
and lamin C, are the most common cause of familial dilated cardiomyopathy (DCM) …

Cardiomyopathies are a heterogeneous group of heart muscle diseases associated with
heart failure, arrhythmias, and death. Genetic variation has a critical role in the pathogenesis …

The M-band is the prominent cytoskeletal structure that cross-links the myosin and titin
filaments in the middle of the sarcomere. To investigate M-band alterations in heart disease …

Dilated cardiomyopathy (DCM) due to mutations in RBM20, a gene encoding an RNA-
binding protein, is associated with high familial penetrance, risk of progressive heart failure …

For inherited cardiomyopathies, abnormal sensitivity to intracellular calcium (Ca2+), incurred
from genetic mutations, initiates subsequent molecular events leading to pathological …

Background—Echocardiographic screening of families with dilated cardiomyopathy has
identified a subgroup of asymptomatic relatives with left ventricular enlargement (LVE). The …

There has been increasing interest on the so-called cardiorenal syndrome (CRS), defined
as a complex pathophysiological disorder of the heart and kidneys whereby acute or chronic …

The cytoskeleton of the cardiomyo-cyte has a special place among the subcellular biological
structures, due to its complexity, its exceptional organisation, and to the multiple roles it …