Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models
M Hittinger, J Juntke, S Kletting… - Advanced drug delivery …, 2015 - Elsevier
New pharmaceutical formulations must be proven as safe and effective before entering
clinical trials. Also in the context of pulmonary drug delivery, preclinical models allow testing …
clinical trials. Also in the context of pulmonary drug delivery, preclinical models allow testing …
[HTML][HTML] Synthesis and Spectrum of Biological Activities of Novel N-arylcinnamamides
S Pospisilova, J Kos, H Michnova… - International Journal of …, 2018 - mdpi.com
A series of sixteen ring-substituted N-arylcinnamamides was prepared and characterized.
Primary in vitro screening of all the synthesized compounds was performed against …
Primary in vitro screening of all the synthesized compounds was performed against …
Synthesis and antimycobacterial properties of ring-substituted 6-hydroxynaphthalene-2-carboxanilides
J Kos, E Nevin, M Soral, I Kushkevych, T Gonec… - Bioorganic & medicinal …, 2015 - Elsevier
In this study, a series of twenty-two ring-substituted 6-hydroxynaphthalene-2-carboxanilides
was prepared and characterized. Primary in vitro screening of the synthesized compounds …
was prepared and characterized. Primary in vitro screening of the synthesized compounds …
[HTML][HTML] Synthesis and Biological Evaluation of N-Alkoxyphenyl-3-hydroxynaphthalene-2-carboxanilides
T Gonec, I Zadrazilova, E Nevin, T Kauerova, M Pesko… - Molecules, 2015 - mdpi.com
A series of fifteen new N-alkoxyphenylanilides of 3-hydroxynaphthalene-2-carboxylic acid
was prepared and characterized. Primary in vitro screening of the synthesized compounds …
was prepared and characterized. Primary in vitro screening of the synthesized compounds …
Ring-substituted 8-hydroxyquinoline-2-carboxanilides as potential antimycobacterial agents
J Kos, I Zadrazilova, E Nevin, M Soral, T Gonec… - Bioorganic & Medicinal …, 2015 - Elsevier
In this study, a series of twenty-two ring-substituted 8-hydroxyquinoline-2-carboxanilides
was prepared and characterized. Primary in vitro screening of the synthesized compounds …
was prepared and characterized. Primary in vitro screening of the synthesized compounds …
[HTML][HTML] Probes and techniques used in active and the hypoxia-based dormant state of an antitubercular drug screening assay
Current antitubercular drug therapy requires more than six months and is unable to kill latent
or dormant forms of tuberculosis. Thus, it is a need of new drug therapy to fight against …
or dormant forms of tuberculosis. Thus, it is a need of new drug therapy to fight against …
[HTML][HTML] N-Alkoxyphenylhydroxynaphthalenecarboxamides and Their Antimycobacterial Activity
T Gonec, S Pospisilova, T Kauerova, J Kos… - Molecules, 2016 - mdpi.com
A series of nineteen N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides and a series
of their nineteen positional isomers N-(alkoxyphenyl)-1-hydroxynaphthalene-2 …
of their nineteen positional isomers N-(alkoxyphenyl)-1-hydroxynaphthalene-2 …
[HTML][HTML] Consensus-Based Pharmacophore Mapping for New Set of N-(disubstituted-phenyl)-3-hydroxyl-naphthalene-2-carboxamides
A Bak, J Kos, H Michnova, T Gonec… - International Journal of …, 2020 - mdpi.com
A series of twenty-two novel N-(disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamide
derivatives was synthesized and characterized as potential antimicrobial agents. N-[3, 5-bis …
derivatives was synthesized and characterized as potential antimicrobial agents. N-[3, 5-bis …
[HTML][HTML] Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides
T Gonec, J Kos, E Nevin, R Govender, M Pesko… - Molecules, 2014 - mdpi.com
In this study, a series of twenty-two ring-substituted naphthalene-1-carboxanilides were
prepared and characterized. Primary in vitro screening of the synthesized carboxanilides …
prepared and characterized. Primary in vitro screening of the synthesized carboxanilides …
[HTML][HTML] Bioactivity of methoxylated and methylated 1-hydroxynaphthalene-2-carboxanilides: Comparative molecular surface analysis
H Michnová, Š Pospíšilová, T Goněc, I Kapustíková… - Molecules, 2019 - mdpi.com
A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene-2-
carboxanilides was prepared and characterized as potential anti-invasive agents. The …
carboxanilides was prepared and characterized as potential anti-invasive agents. The …