Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

M Hittinger, J Juntke, S Kletting… - Advanced drug delivery …, 2015 - Elsevier
New pharmaceutical formulations must be proven as safe and effective before entering
clinical trials. Also in the context of pulmonary drug delivery, preclinical models allow testing …

[HTML][HTML] Synthesis and Spectrum of Biological Activities of Novel N-arylcinnamamides

S Pospisilova, J Kos, H Michnova… - International Journal of …, 2018 - mdpi.com
A series of sixteen ring-substituted N-arylcinnamamides was prepared and characterized.
Primary in vitro screening of all the synthesized compounds was performed against …

Synthesis and antimycobacterial properties of ring-substituted 6-hydroxynaphthalene-2-carboxanilides

J Kos, E Nevin, M Soral, I Kushkevych, T Gonec… - Bioorganic & medicinal …, 2015 - Elsevier
In this study, a series of twenty-two ring-substituted 6-hydroxynaphthalene-2-carboxanilides
was prepared and characterized. Primary in vitro screening of the synthesized compounds …

[HTML][HTML] Synthesis and Biological Evaluation of N-Alkoxyphenyl-3-hydroxynaphthalene-2-carboxanilides

T Gonec, I Zadrazilova, E Nevin, T Kauerova, M Pesko… - Molecules, 2015 - mdpi.com
A series of fifteen new N-alkoxyphenylanilides of 3-hydroxynaphthalene-2-carboxylic acid
was prepared and characterized. Primary in vitro screening of the synthesized compounds …

Ring-substituted 8-hydroxyquinoline-2-carboxanilides as potential antimycobacterial agents

J Kos, I Zadrazilova, E Nevin, M Soral, T Gonec… - Bioorganic & Medicinal …, 2015 - Elsevier
In this study, a series of twenty-two ring-substituted 8-hydroxyquinoline-2-carboxanilides
was prepared and characterized. Primary in vitro screening of the synthesized compounds …

[HTML][HTML] Probes and techniques used in active and the hypoxia-based dormant state of an antitubercular drug screening assay

A Yeware, S Akhtar, D Sarkar - Medicine in Drug Discovery, 2022 - Elsevier
Current antitubercular drug therapy requires more than six months and is unable to kill latent
or dormant forms of tuberculosis. Thus, it is a need of new drug therapy to fight against …

[HTML][HTML] N-Alkoxyphenylhydroxynaphthalenecarboxamides and Their Antimycobacterial Activity

T Gonec, S Pospisilova, T Kauerova, J Kos… - Molecules, 2016 - mdpi.com
A series of nineteen N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides and a series
of their nineteen positional isomers N-(alkoxyphenyl)-1-hydroxynaphthalene-2 …

[HTML][HTML] Consensus-Based Pharmacophore Mapping for New Set of N-(disubstituted-phenyl)-3-hydroxyl-naphthalene-2-carboxamides

A Bak, J Kos, H Michnova, T Gonec… - International Journal of …, 2020 - mdpi.com
A series of twenty-two novel N-(disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamide
derivatives was synthesized and characterized as potential antimicrobial agents. N-[3, 5-bis …

[HTML][HTML] Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides

T Gonec, J Kos, E Nevin, R Govender, M Pesko… - Molecules, 2014 - mdpi.com
In this study, a series of twenty-two ring-substituted naphthalene-1-carboxanilides were
prepared and characterized. Primary in vitro screening of the synthesized carboxanilides …

[HTML][HTML] Bioactivity of methoxylated and methylated 1-hydroxynaphthalene-2-carboxanilides: Comparative molecular surface analysis

H Michnová, Š Pospíšilová, T Goněc, I Kapustíková… - Molecules, 2019 - mdpi.com
A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene-2-
carboxanilides was prepared and characterized as potential anti-invasive agents. The …