Streptococcus pneumoniae has a complex relationship with its obligate human host. On the
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …

Classically, the CNS is described as displaying immune privilege, as it shows attenuated
responses to challenge by alloantigen. However, the CNS does show local inflammation in …

The brain is well protected against microbial invasion by cellular barriers, such as the blood-
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …

The blood–brain barrier, which is one of the tightest barriers in the body, protects the brain
from insults, such as infections. Indeed, only a few of the numerous blood-borne bacteria …

Acute bacterial meningitis : Current Opinion in Neurology Acute bacterial meningitis :
Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get new …

Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter
the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics …

Central nervous system (CNS) infections continue to be an important cause of morbidity and
mortality. Microbial invasion and traversal of the blood–brain barrier is a prerequisite for …

Bacterial meningitis is a devastating disease occurring worldwide with up to half of the
survivors left with permanent neurological sequelae. Due to intrinsic properties of the …

Streptococcus pneumoniae is a common human nasopharyngeal commensal colonizing
10% to 40% of healthy individuals, depending on age. Despite a low invasive disease rate …

Diseases caused by Streptococcus pneumoniae include pneumonia, septicaemia and
meningitis. All these are associated with high morbidity and mortality. The pneumococcus …