The emergence of immune checkpoint blockade therapies over the last decade has
transformed cancer treatment in a wide range of tumor types. Unprecedented and durable …

In the wake of the success of modern immunotherapy, oncolytic viruses (OVs) are currently
seen as a potential therapeutic option for patients with cancer who do not respond or fail to …

Disclosures: SA Vardhana reported personal fees from Immunai and personal fees from
ADC Therapeutics outside the submitted work; in addition, SA Vardhana had a patent to …

Our recently published research on the characterization of vesicular stomatitis virus (VSV)
pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the …

The immune system maintains a critically organized network to defend against foreign
particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors …

For the first time in decades, patients with difficult-to-treat cancers such as advanced stage
metastatic melanoma are being offered a glimpse of hope in the form of immunotherapies …

Cancer development and its response to therapy are strongly influenced by innate and
adaptive immunity, which either promote or attenuate tumorigenesis and can have opposing …

Abstract Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated
promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we …

T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections
and cancer. It is defined by poor effector function, sustained expression of inhibitory …

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and
to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP …