Diabetic wound shows delayed and incomplete healing processes, which in turn exposes
patients to an environment with a high risk of infection. This article has summarized current …

Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

Maladaptive changes of nerve injury–associated genes in dorsal root ganglia (DRGs) are
critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding …

Background Chronic inflammatory pain significantly reduces the quality of life and lacks
effective interventions. In recent years, human umbilical cord mesenchymal stem cells (huc …

Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …

Background Xanthenes are a special class of oxygen-incorporating tricyclic compounds.
Structurally related to xanthones, the presence of different substituents in position 9 strongly …

Background Complex regional pain syndrome type-I (CRPS-I) causes excruciating pain that
affect patients' life quality. However, the mechanisms underlying CRPS-I are incompletely …

Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-
effects of therapies. Astrocytes are the most abundant glial cells in the central nervous …

In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of
melatonin (MLT) on neuropathic pain (NP)-induced anxiety and depression in a rat model …

Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …