Neuropathic pain is one of the most severe forms of chronic pain caused by the direct injury
of the somatosensory system. The current drugs for treating neuropathies have limited …

Purpose The aim of this study was to investigate the effect of Zhiqiao Gancao decoction
(ZQGCD) on hyperalgesia in lumbar disc herniation (LDH) and its mechanism. Methods The …

Neuropathic cancer pain (NCP) is an important symptom in patients with cancer. However,
significant analgesic tolerance and other side effects critically hamper the administration of …

The insular cortex (IC) is known to process pain information. However, analgesic effects of
glial inhibition in the IC have not yet been explored. The aim of this study was to investigate …

Bone marrow‐derived mesenchymal stem cells (BMSCs) show a good property for pain
treatment by modulating inflammatory response. However, the underlying therapeutic effect …

Background Chronic pain is defined as pain that persists typically for a period of over six
months. Chronic pain is often accompanied by an anxiety disorder, and these two tend to …

Chronic pain affects patients' physical and psychological health and quality of life, entailing
a tremendous public health challenge. Currently, drugs for chronic pain are usually …

Perineural invasion (PNI) is a notorious feature of salivary adenoid cystic carcinoma (SACC)
and other neurotropic tumors. The pathogenesis of PNI that involves the molecular …

Peripheral neuropathy (PN) is a severe and frequent complication of obesity, prediabetes,
and type 2 diabetes characterized by progressive distal-to-proximal peripheral nerve …

Diabetic foot ulcers, burns and many other trauma can lead to the formation of skin wounds,
which often remain open for a long period of time, seriously affecting the quality of patient's …