Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Diabetes prevalence is increasing rapidly in older people, and sarcopenia is prevalent as a
novel complication, particularly in patients with type 2 diabetes mellitus (T2DM). Therefore …

Background Sarcopenic obesity is a highly prevalent disease with poor survival and
ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the …

Insulin resistance is one of the earliest pathological features of a suite of diseases including
type 2 diabetes collectively referred to as metabolic syndrome. There is a growing body of …

Metabolic syndrome (MetS) is a common feature in obesity, comprising a cluster of
abnormalities including abdominal fat accumulation, hyperglycemia, hyperinsulinemia …

The continuous dynamic reshaping of mitochondria by fusion and fission events is critical to
keep mitochondrial quality and function under control in response to changes in energy and …

Mitochondria-endoplasmic/sarcoplasmic reticulum (ER/SR) interaction and mitochondrial
fusion/fission are critical processes that influence substrate oxidation. This narrative review …

Objective One of the suggested mechanisms of obesity-induced insulin resistance is
mitochondrial dysfunction in target tissues such as skeletal muscle. In our study, we …

Objective SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on
cardiovascular and renal outcomes; the underlying mechanism may be metabolic …

Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the
elderly population worldwide. It is characterized by a progressive decline in muscle mass …