For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …

Glioblastoma multiforme (GBM) is the most common and fatal primary malignant central
nervous system tumor in adults. Although there are multiple treatments, the median survival …

Despite the remarkable progress in cancer treatment up to now, we are still far from
conquering the disease. The most substantial change after the malignant transformation of …

The expression of genes of various proinflammatory chemokines and cytokines is controlled,
among others, by the signaling pathway of the nuclear factor kappaB (NF-κB) superfamily of …

Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

The transcription factor, sterol regulatory element binding protein 1 (SREBP-1), plays
important roles in modulating the proliferation, metastasis, or resistance to antitumor agents …

Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require
conservative treatment with progestin, and its underlying mechanisms remain unclear. YAP …

Background The effectiveness of conservative treatment of endometrial carcinoma (EC) with
oral progesterone therapy, such as medroxyprogesterone acetate (MPA), can be blunted …

The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple
tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and …