Poorly controlled postoperative pain is associated with increased morbidity, negatively
affects quality of life and functional recovery, and is a risk factor for persistent pain and …

Peripherally acting μ-opioid receptor antagonists (PAMORAs) constitute a class of drugs
which reverse opioid-induced constipation (OIC) with similar opioid analgesic effects. OIC …

Purpose To provide evidence-based guidance on the optimum management of chronic pain
in adult cancer survivors. Methods An ASCO-convened expert panel conducted a systematic …

ONC201/TIC10 is a first-in-class small molecule inducer of TRAIL that causes early
activation of the integrated stress response. Its promising safety profile and broad-spectrum …

Background Methylnaltrexone (MNTX), a peripherally acting μ-opioid receptor (MOR)
antagonist, is FDA-approved for treatment of opioid-induced constipation (OIC). Preclinical …

Aim: Retrospective studies have suggested a protective effect of regional anesthesia against
recurrence after cancer surgery. But confirmation of the in vivo antitumor effects is lacking …

Background Opioids have been linked to worse oncologic outcomes in surgical patients.
Studies in certain cancer types have identified associations between survival and intra …

Background Pain is associated with shorter survival in non-small cell lung cancer (NSCLC).
Lung cancer cells express opioid receptors. Opioids promote angiogenesis, tumour growth …

Purpose Pain commonly occurs in cancer patients, and has been associated with shorter
survival. However, the importance of pain is less clear when analyzed with other known …

Abdominal pain is an important symptom in most patients with pancreatic ductal
adenocarcinoma (PDAC). Adequate control of pain is often unsatisfactory due to limited …