The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links
extracellular signals to the control of cell survival, growth, proliferation and differentiation …

Recent studies conducted over the past 10 years evidence the intriguing role of the tumor
suppressor gene Phosphatase and Tensin Homolog deleted on Chromosome 10 PTEN in …

Lung cancer is one of the leading causes of death in both males and females, and it is the
first causes of cancer-related deaths. Chemotherapy, surgery and radiotherapy are …

Lung cancer is the most common malignancy and cause of cancer deaths worldwide, owing
to the dismal prognosis for most affected patients. Phosphatase and tensin homolog deleted …

Chemoresistance has doubled the effort needed to reach an effective treatment for cancer.
Now, scientists should consider molecular pathways and mechanisms involved in …

Doxorubicin is conventionally used in chemotherapy against hepatocellular carcinoma
(HCC), but acquired resistance developed during long-term therapy limits its benefits …

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that
is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to …

PTENα and PTENβ are two longer translational variants of phosphatase and tensin homolog
(PTEN) messenger RNA. Their expressional regulations and functions in carcinogenesis …

Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear
PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However …

Gastric cancer is the third most common cause of cancer-related death worldwide. Drug
resistance is the main inevitable and vital factor leading to a low 5-year survival rate for …