The FOX family of transcription factors was originally identified in 1989, comprising the
FOXA to FOXS subfamilies. FOXO3, a well-known member of the FOXO subfamily, is widely …

Circadian rhythms are physical, behavioral and environmental cycles that respond primarily
to light and dark, with a period of time of approximately 24 h. The most essential …

Lipid nanoparticles (LNPs) exhibit remarkable mRNA delivery efficiency, yet their majority
accumulate in the liver or spleen after injection. Tissue‐specific mRNA delivery can be …

Aging of hematopoietic stem cells (HSCs) directly contributes to dysfunction of
hematopoietic and immune systems due to aging-associated alterations in HSC features …

Purpose Cancer cells require a supply of amino acids, particularly essential amino acids
such as branched-chain amino acids (BCAAs, ie, valine, leucine, and isoleucine), to meet …

Spontaneous intracerebral hemorrhage (ICH) commonly causes secondary hippocampal
damage and delayed cognitive impairments, but the mechanisms remain elusive. Here, we …

PTEN is a crucial tumor suppressor and loss of PTEN protein is involved in various cancers.
However, the detailed molecular mechanisms of PTEN loss in cancers remain elusive …

Photodynamic therapy (PDT) is widely used for the treatment of hypertrophic scars in clinical
practice. However, the low transdermal delivery of photosensitizers in scar tissue and …

Autophagy has been reported to be involved in the occurrence and development of
pancreatic cancer. However, the mechanism of autophagy‑associated non‑coding RNAs …

Dysregulation of autophagy has been implicated in the development of many diseases,
including cancer. Here, we revealed a novel function of the E3 ubiquitin ligase HRD1 in non …