Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with a poor
prognosis due to a lack of early detection. Indeed, the mechanisms underlying ESCC …

Cardiac remodeling occurs after the heart is exposed to stress, which is manifested by
pathological processes such as cardiomyocyte hypertrophy and apoptosis, dendritic cells …

Ubiquitin (Ub) and ubiquitin-like (Ubl) pathways are critical post-translational modifications
that determine whether functional proteins are degraded or activated/inactivated. To date,> …

Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein
ligase (Nedd4-1 and Nedd4-2) is a member of the HECT E3 ubiquitin ligase family. It has …

Autophagy is a conserved cellular self-digesting process that degrades obsoleting proteins
and cellular components and plays a crucial role in the tumorigenesis, metastasis, and drug …

Ascomylactam A was reported for the first time as a new 13-membered-ring macrocyclic
alkaloid in 2019 from the mangrove endophytic fungus Didymella sp. CYSK-4 from the …

Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis
and is responsible for the quality control of proteins, organelles, and energy metabolism …

Long non-coding RNAs (lncRNAs) are emerging as a new class of regulators for a variety of
biological processes and have been suggested to play pivotal roles in cancer development …

Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with limited
treatment options and poor prognosis. In this study, we reveal the pivotal role of Stratifin …

Members of the HECT family of E3 ubiquitin ligases have emerged as prominent regulators
of PTEN function, subcellular localization and levels. In turn this unfolding regulatory …