USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer

M Zhu, H Zhang, F Lu, Z Wang, Y Wu, H Chen… - Bioscience …, 2021 - portlandpress.com
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer.
Ubiquitination is closely related to the development of lung cancer. However, the biological …

[HTML][HTML] BAMLET (Bovine α-lactalbumin made lethal to tumor cells) inhibits autophagy flux and induces apoptosis via down-regulation of protein kinase CK1α and …

H Behrouj, P Mokarram - Iranian Journal of Basic Medical …, 2023 - ncbi.nlm.nih.gov
Objective (s): Oncogenic RAS mutations occur in nearly 50% of colorectal cancer cases and
are usually dependent on the autophagy mechanism to maintain tumorigenesis. We have …

Mechanistic insights and implications of FOXO‐SNAI interplay

X Guo, C Wu, Y Pan, X Zhu, K Peng, X Ma, L Xue - BioEssays, 2022 - Wiley Online Library
Autophagy promotes both health and disease, depending on tissue types and genetic
contexts, yet the regulatory mechanism remain incompletely understood. Our recent …

[HTML][HTML] A Meroterpenoid from Tibetan medicine induces lung cancer cells apoptosis through ROS-mediated inactivation of the AKT pathway

Y Huang, Y Huang, G Zhu, B Zhang, Y Zhu, B Chen… - Molecules, 2023 - mdpi.com
As a traditional Tibetan medicine in China, Meconopsis grandis Prain has been used to treat
a variety of illnesses by local people for thousands of years. However, the active ingredients …

[HTML][HTML] TMEM100 induces cell death in non‑small cell lung cancer via the activation of autophagy and apoptosis

Q He, Y Dong, Y Zhu, Z Ding, X Zhang… - Oncology …, 2021 - spandidos-publications.com
Lung cancer is one of the most malignant type of tumors worldwide. Non‑small cell lung
cancer (NSCLC), which is the most common type of lung cancer, is defined as a distinct …

[HTML][HTML] β2‑adrenergic receptor signaling promotes neuroblastoma cell proliferation by activating autophagy

J Deng, P Jiang, T Yang, M Huang… - Oncology …, 2019 - spandidos-publications.com
Accumulating evidence suggests the pivotal role of the sympathetic nervous system in the
initiation and aggressive progression of tumors, whereas the role of β‑adrenergic receptor (β …

[HTML][HTML] MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN

J Huang, Y Zhang, Y Xu, Q Xie, S Wu, Y Dong… - Journal of …, 2021 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is still one of the leading causes of cancer-associated death in the
modern society. The biological function of miR-202-5p for CRC development remains …

[HTML][HTML] Autophagy characteristics and establishment of autophagy prognostic models in lung adenocarcinoma and lung squamous cell carcinoma

Z Chen, H Xiong, H Shen, Q You - PLoS One, 2022 - journals.plos.org
Background Non-small cell lung cancer (NSCLC), which makes up the majority of lung
cancers, remains one of the deadliest malignancies in the world. It has a poor prognosis due …

[HTML][HTML] Fuzheng Kang'ai decoction (扶正抗癌方) inhibits cell proliferation, migration and invasion by modulating mir-21-5p/human phosphatase and tensin homology …

LI Jinhua, L Chunping, Z Yueyang… - Journal of Traditional …, 2022 - ncbi.nlm.nih.gov
OBJECTIVE: To elucidate the potential molecular mechanism by which Fuzheng Kang'ai
decoction (扶正抗癌方, FZKA) inhibits proliferation, migration, and invasion of lung cancer …

Therapeutic potential of autophagy activators and inhibitors in lung and breast cancer-a review

P Mudaliar, A Nalawade, S Devarajan, J Aich - Molecular Biology Reports, 2022 - Springer
Autophagy is a cellular process that eliminates damaged components of cytoplasm via the
lysosome. Autophagy supports cells and tissues to remain healthy by recycling old or …