[HTML][HTML] Biological functions of autophagy genes: a disease perspective
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
Increasing clinical evidence has demonstrated that the deletion or mutation of tumor
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
Mitochondria‐specific nanocatalysts for chemotherapy‐augmented sequential chemoreactive tumor therapy
Endogenic tumor chemodynamic therapy (CDT) is emerging as a tumor‐therapeutic strategy
featuring in situ treatments with high efficiency and specificity based on the Fenton reaction …
featuring in situ treatments with high efficiency and specificity based on the Fenton reaction …
The V-ATPases in cancer and cell death
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …
Crosstalk between autophagy and microbiota in cancer progression
Y Wang, J Du, X Wu, A Abdelrehem, Y Ren, C Liu… - Molecular Cancer, 2021 - Springer
Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a
lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often …
lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often …
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
Lung cancer often has a poor prognosis, with brain metastases a major reason for mortality.
We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria …
We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria …
Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
X Wang, G Qin, X Liang, W Wang, Z Wang… - Nature …, 2020 - nature.com
Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks
therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed …
therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed …
SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer
Y Lv, W Zhang, J Zhao, B Sun, Y Qi, H Ji… - … and Targeted Therapy, 2021 - nature.com
Alternative splicing is a critical process to generate protein diversity. However, whether and
how alternative splicing regulates autophagy remains largely elusive. Here we …
how alternative splicing regulates autophagy remains largely elusive. Here we …