Colorectal cancer (CRC) develops through a multistage process that results from the
progressive accumulation of genetic mutations, and frequently as a result of mutations in the …

Despite new and more effective cytotoxic chemotherapy, limitations to conventional agents
have been reached in a subset of patients with advanced colorectal cancer (CRC). The …

The promise of personalised medicine is now a clinical reality, with colorectal cancer
genetics at the forefront of this next major advance in clinical medicine. This is no more …

Background Mutation of BRAF is a predominant event in cancers with poor prognosis such
as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of …

Immune cells in the tumor microenvironment have an important role in regulating tumor
progression. Therefore, stimulating immune reactions to tumors can be an attractive …

Purpose: To assess prognostic roles of various KRAS oncogene mutations in colorectal
cancer, BRAF mutation status must be controlled for because BRAF mutation is associated …

Purpose: The purpose of this study was to examine the prognostic and oxaliplatin predictive
value of mismatch repair (MMR) status and common hot spot mutations, which we previously …

Colorectal cancer (CRC) is a common malignancy and the fourth leading cause of cancer
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …

Purpose: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major
drivers in colorectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with …

Recent literature suggests an increasing incidence of colorectal carcinoma in young
patients. We performed a histologic, molecular, and immunophenotypic analysis of patients …