[HTML][HTML] Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis
Background Divergent findings regarding the prognostic value of CpG island methylator
phenotype (CIMP) in colorectal cancer (CRC) patients exist in current literature. We aim to …
phenotype (CIMP) in colorectal cancer (CRC) patients exist in current literature. We aim to …
[HTML][HTML] BRAF mutated colorectal cancer: New treatment approaches
J Molina-Cerrillo, M San Román, J Pozas… - Cancers, 2020 - mdpi.com
Colon cancer is one of the most frequently diagnosed malignancies in adults, considering
both its incidence and prevalence. Anatomically, the right colon is considered as being from …
both its incidence and prevalence. Anatomically, the right colon is considered as being from …
Three DNA methylation epigenotypes in human colorectal cancer
K Yagi, K Akagi, H Hayashi, G Nagae, S Tsuji… - Clinical Cancer …, 2010 - AACR
Abstract Purpose: Whereas the CpG island methylator phenotype (CIMP) in colorectal
cancer associates with microsatellite instability (MSI)-high and BRAF-mutation (+), the …
cancer associates with microsatellite instability (MSI)-high and BRAF-mutation (+), the …
Clinicopathological relevance of BRAF mutations in human cancer
S Pakneshan, A Salajegheh, RA Smith… - Pathology-Journal of …, 2013 - journals.lww.com
BRAF represents one of the most frequently mutated protein kinase genes in human
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …
[HTML][HTML] Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease
Epigenetics acts as an interface between environmental/exogenous factors, cellular
responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of …
responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of …
5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer
R Jover, TP Nguyen, L Pérez–Carbonell, P Zapater… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: 5-Fluorouracil (5-FU)–based adjuvant chemotherapy does not
increase survival times of patients with colorectal tumors with microsatellite instability. We …
increase survival times of patients with colorectal tumors with microsatellite instability. We …
BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse …
The association of BRAF V600E mutation and the presence of the CpG island methylator
phenotype (CIMP) and microsatellite instability (MSI) often confound analysis of BRAF …
phenotype (CIMP) and microsatellite instability (MSI) often confound analysis of BRAF …
KRAS Mutation in Stage III Colon Cancer and Clinical Outcome Following Intergroup Trial CALGB 89803
S Ogino, JA Meyerhardt, N Irahara, D Niedzwiecki… - Clinical cancer …, 2009 - AACR
Purpose: Alterations in the RAS and RAF pathway relate to epigenetic and epigenomic
aberrations, and are important in colorectal carcinogenesis. KRAS mutation in metastatic …
aberrations, and are important in colorectal carcinogenesis. KRAS mutation in metastatic …
[HTML][HTML] Review of histopathological and molecular prognostic features in colorectal cancer
O Marzouk, J Schofield - Cancers, 2011 - mdpi.com
Prediction of prognosis in colorectal cancer is vital for the choice of therapeutic options.
Histopathological factors remain paramount in this respect. Factors such as tumor size …
Histopathological factors remain paramount in this respect. Factors such as tumor size …
[HTML][HTML] Microsatellite instability in colorectal cancers: carcinogenesis, neo-antigens, immuno-resistance and emerging therapies
V Randrian, C Evrard, D Tougeron - Cancers, 2021 - mdpi.com
Simple Summary A deficient mismatch repair system (dMMR) results in microsatellite
instability (MSI). The MSI status of a tumor predicts the response to immune checkpoint …
instability (MSI). The MSI status of a tumor predicts the response to immune checkpoint …