Tandem repeat variation in human and great ape populations and its impact on gene expression divergence
TB Sonay, T Carvalho, MD Robinson… - Genome …, 2015 - genome.cshlp.org
Tandem repeats (TRs) are stretches of DNA that are highly variable in length and mutate
rapidly. They are thus an important source of genetic variation. This variation is highly …
rapidly. They are thus an important source of genetic variation. This variation is highly …
A generic, cost-effective, and scalable cell lineage analysis platform
Advances in single-cell genomics enable commensurate improvements in methods for
uncovering lineage relations among individual cells. Current sequencing-based methods for …
uncovering lineage relations among individual cells. Current sequencing-based methods for …
Retrospective cell lineage reconstruction in humans by using short tandem repeats
Cell lineage analysis aims to uncover the developmental history of an organism back to its
cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important …
cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important …
[HTML][HTML] CRISPR-Cas9 targeted enrichment and next-generation sequencing for mutation detection
Despite the rapid application of next-generation sequencing (NGS) technologies, target
sequencing in regions of the genome is often required to diagnose many genetic diseases …
sequencing in regions of the genome is often required to diagnose many genetic diseases …
Massive variation of short tandem repeats with functional consequences across strains of Arabidopsis thaliana
Short tandem repeat (STR) mutations may comprise more than half of the mutations in
eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex …
eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex …
Challenges and approaches to genotyping repetitive DNA
EA Morton, AN Hall, E Kwan, C Mok… - G3: Genes …, 2020 - academic.oup.com
Individuals within a species can exhibit vast variation in copy number of repetitive DNA
elements. This variation may contribute to complex traits such as lifespan and disease, yet it …
elements. This variation may contribute to complex traits such as lifespan and disease, yet it …
The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model
Functional short tandem repeats (STR) are polymorphic in the population, and the number of
repeats regulates the expression of nearby genes (known as expression STR, eSTR). STR …
repeats regulates the expression of nearby genes (known as expression STR, eSTR). STR …
Genome scans for divergent selection in natural populations of the widespread hardwood species Eucalyptus grandis (Myrtaceae) using microsatellites
Z Song, M Zhang, F Li, Q Weng, C Zhou, M Li, J Li… - Scientific reports, 2016 - nature.com
Identification of loci or genes under natural selection is important for both understanding the
genetic basis of local adaptation and practical applications, and genome scans provide a …
genetic basis of local adaptation and practical applications, and genome scans provide a …
An improved molecular inversion probe based targeted sequencing approach for low variant allele frequency
T Biezuner, Y Brilon, AB Arye, B Oron… - NAR genomics and …, 2022 - academic.oup.com
Deep targeted sequencing technologies are still not widely used in clinical practice due to
the complexity of the methods and their cost. The Molecular Inversion Probes (MIP) …
the complexity of the methods and their cost. The Molecular Inversion Probes (MIP) …
[HTML][HTML] From genome sequencing to the discovery of potential biomarkers in liver disease
S Oh, Y Jo, S Jung, S Yoon, KH Yoo - BMB reports, 2020 - ncbi.nlm.nih.gov
Chronic liver disease progresses through several stages, fatty liver, steatohepatitis, cirrhosis,
and eventually, it leads to hepatocellular carcinoma (HCC) over a long period of time. Since …
and eventually, it leads to hepatocellular carcinoma (HCC) over a long period of time. Since …