Tandem repeats (TRs) are stretches of DNA that are highly variable in length and mutate
rapidly. They are thus an important source of genetic variation. This variation is highly …

Advances in single-cell genomics enable commensurate improvements in methods for
uncovering lineage relations among individual cells. Current sequencing-based methods for …

Cell lineage analysis aims to uncover the developmental history of an organism back to its
cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important …

Despite the rapid application of next-generation sequencing (NGS) technologies, target
sequencing in regions of the genome is often required to diagnose many genetic diseases …

Short tandem repeat (STR) mutations may comprise more than half of the mutations in
eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex …

Individuals within a species can exhibit vast variation in copy number of repetitive DNA
elements. This variation may contribute to complex traits such as lifespan and disease, yet it …

Functional short tandem repeats (STR) are polymorphic in the population, and the number of
repeats regulates the expression of nearby genes (known as expression STR, eSTR). STR …

Identification of loci or genes under natural selection is important for both understanding the
genetic basis of local adaptation and practical applications, and genome scans provide a …

Deep targeted sequencing technologies are still not widely used in clinical practice due to
the complexity of the methods and their cost. The Molecular Inversion Probes (MIP) …

Chronic liver disease progresses through several stages, fatty liver, steatohepatitis, cirrhosis,
and eventually, it leads to hepatocellular carcinoma (HCC) over a long period of time. Since …