The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …

This article reviews recent advances in the biochemistry and molecular biology of 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific pulmonary car …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
tobacco products, and exposure to it is likely one of the factors contributing to the …

Administration of delavirdine, an HIV-1 reverse transcriptase inhibitor, to rats or monkeys
resulted in apparent loss of hepatic microsomal CYP3A and delavirdine desalkylation …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
both unburned tobacco and cigarette smoke. The sum of 4-(methylnitrosamino)-1-(3-pyridyl) …

An IARC Advisory Group to Recommend Priorities for IARC Monographs during 2015–2019
met in Lyon, France, on 7–9 April 2014. Before the meeting, IARC solicited nominations of …

Tobacco-specific A-nitrosamines (TSNA) are the most abundant, strong carcino gens in
tobacco smoke. Seven TSNA have been identified in tobacco products: N'-nitrosonornicotine …

The carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and N '-nitrosonornicotine (NNN) are believed to play a role in cancers …

Model studies have shown that the reaction of nicotine with nitrous acid in aqueous solution
at pH 3.4 and 20 C yields three nitrosation products; 4-(methylnitrosamino)-4-(3-pyridyl) …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a chiral compound, and the primary
metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a major carcinogen in …