Cardiac energy metabolism in heart failure
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …
the energy metabolic changes that occur in heart failure are complex and are dependent not …
[HTML][HTML] Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus
K Nakamura, T Miyoshi, M Yoshida, S Akagi… - International journal of …, 2022 - mdpi.com
There is a close relationship between diabetes mellitus and heart failure, and diabetes is an
independent risk factor for heart failure. Diabetes and heart failure are linked by not only the …
independent risk factor for heart failure. Diabetes and heart failure are linked by not only the …
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …
may increase the risk for heart failure development. This risk evolves from functional and …
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities
I Tuleta, NG Frangogiannis - Advanced drug delivery reviews, 2021 - Elsevier
In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …
[HTML][HTML] Diabetic cardiomyopathy: Early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions
JL Huo, Q Feng, S Pan, WJ Fu, Z Liu, Z Liu - Cell death discovery, 2023 - nature.com
Diabetic cardiomyopathy (DCM) mainly refers to myocardial metabolic dysfunction caused
by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the …
by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the …
The role of aldehyde dehydrogenase 2 in cardiovascular disease
J Zhang, Y Guo, X Zhao, J Pang, C Pan… - Nature Reviews …, 2023 - nature.com
Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …
NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways
L Meng, Y Lu, X Wang, C Cheng, F Xue, L Xie… - Science …, 2023 - science.org
Cardiac fibrosis plays a key role in the progression of diabetic cardiomyopathy (DCM).
Previous studies demonstrated the cardioprotective effects of natriuretic peptides. However …
Previous studies demonstrated the cardioprotective effects of natriuretic peptides. However …
The molecular mechanisms of defective copper metabolism in diabetic cardiomyopathy
X Cui, Y Wang, H Liu, M Shi, J Wang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …
pathology by regulating various important biological processes, including mitochondrial …
KLF5 is induced by FOXO1 and causes oxidative stress and diabetic cardiomyopathy
ID Kyriazis, M Hoffman, L Gaignebet… - Circulation …, 2021 - Am Heart Assoc
Rationale: Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes,
accompanied by altered cardiac energetics, impaired mitochondrial function, and oxidative …
accompanied by altered cardiac energetics, impaired mitochondrial function, and oxidative …