Personalized medicine: motivation, challenges, and progress

LH Goetz, NJ Schork - Fertility and sterility, 2018 - Elsevier
There is a great deal of hype surrounding the concept of personalized medicine.
Personalized medicine is rooted in the belief that since individuals possess nuanced and …

Disruption of circadian rhythms: a crucial factor in the etiology of infertility

F Sciarra, E Franceschini, F Campolo… - International journal of …, 2020 - mdpi.com
Infertility represents a growing health problem in industrialized countries. Thus, a greater
understanding of the molecular networks involved in this disease could be critical for the …

Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells

F Gao, G Li, C Liu, H Gao, H Wang, W Liu… - Journal of Cell …, 2018 - rupress.org
Testosterone is indispensable for sexual development and maintaining male characteristics,
and deficiency of this hormone results in primary or late-onset hypogonadism (LOH) …

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion

L Zeng, J Zhou, X Wang, Y Zhang, M Wang… - Free Radical Biology and …, 2021 - Elsevier
Ferroptosis is a newly defined programmed cell death pathway characterized by iron
overload and lipid peroxidation. Increasing studies show that autophagy regulates …

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

N Barban, R Jansen, R De Vlaming, A Vaez… - Nature …, 2016 - nature.com
The genetic architecture of human reproductive behavior—age at first birth (AFB) and
number of children ever born (NEB)—has a strong relationship with fitness, human …

Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis

JU Igietseme, Y Omosun, O Stuchlik, MS Reed… - PloS one, 2015 - journals.plos.org
Chlamydia trachomatis genital infection in women causes serious adverse reproductive
complications, and is a strong co-factor for human papilloma virus (HPV)-associated cervical …

Research trends and perspectives of male infertility: a bibliometric analysis of 20 years of scientific literature

Y Zhang, F Xiao, S Lu, J Song, C Zhang, J Li, K Gu… - …, 2016 - Wiley Online Library
To carry out an in‐depth analysis of the scientific research on male infertility, we performed
the first bibliometric analysis focusing on studies involving male infertility worldwide during …

Role of Macroautophagy in Mammalian Male Reproductive Physiology

D Kirat, AM Alahwany, AH Arisha, A Abdelkhalek… - Cells, 2023 - mdpi.com
Physiologically, autophagy is an evolutionarily conserved and self-degradative process in
cells. Autophagy carries out normal physiological roles throughout mammalian life …

Serum opacity factor rescues fertility among female Scarb1−/− mice by reducing HDL-free cholesterol bioavailability

C Rosales, D Yelamanchili, BK Gillard, J Liu… - Journal of Lipid …, 2023 - ASBMB
Human female infertility, 20% of which is idiopathic, is a public health problem for which
better diagnostics and therapeutics are needed. A novel cause of infertility emerged from …

The effects of cholesterol metabolism on follicular development and ovarian function

Q Huang, Y Liu, Z Yang, Y Xie… - Current Molecular …, 2019 - ingentaconnect.com
Cholesterol is an important substrate for the synthesis of ovarian sex hormones and has an
important influence on follicular development. The cholesterol in follicular fluid is mainly …