Personalized medicine: motivation, challenges, and progress
LH Goetz, NJ Schork - Fertility and sterility, 2018 - Elsevier
There is a great deal of hype surrounding the concept of personalized medicine.
Personalized medicine is rooted in the belief that since individuals possess nuanced and …
Personalized medicine is rooted in the belief that since individuals possess nuanced and …
Disruption of circadian rhythms: a crucial factor in the etiology of infertility
F Sciarra, E Franceschini, F Campolo… - International journal of …, 2020 - mdpi.com
Infertility represents a growing health problem in industrialized countries. Thus, a greater
understanding of the molecular networks involved in this disease could be critical for the …
understanding of the molecular networks involved in this disease could be critical for the …
Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells
Testosterone is indispensable for sexual development and maintaining male characteristics,
and deficiency of this hormone results in primary or late-onset hypogonadism (LOH) …
and deficiency of this hormone results in primary or late-onset hypogonadism (LOH) …
Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion
L Zeng, J Zhou, X Wang, Y Zhang, M Wang… - Free Radical Biology and …, 2021 - Elsevier
Ferroptosis is a newly defined programmed cell death pathway characterized by iron
overload and lipid peroxidation. Increasing studies show that autophagy regulates …
overload and lipid peroxidation. Increasing studies show that autophagy regulates …
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
The genetic architecture of human reproductive behavior—age at first birth (AFB) and
number of children ever born (NEB)—has a strong relationship with fitness, human …
number of children ever born (NEB)—has a strong relationship with fitness, human …
Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis
JU Igietseme, Y Omosun, O Stuchlik, MS Reed… - PloS one, 2015 - journals.plos.org
Chlamydia trachomatis genital infection in women causes serious adverse reproductive
complications, and is a strong co-factor for human papilloma virus (HPV)-associated cervical …
complications, and is a strong co-factor for human papilloma virus (HPV)-associated cervical …
Research trends and perspectives of male infertility: a bibliometric analysis of 20 years of scientific literature
Y Zhang, F Xiao, S Lu, J Song, C Zhang, J Li, K Gu… - …, 2016 - Wiley Online Library
To carry out an in‐depth analysis of the scientific research on male infertility, we performed
the first bibliometric analysis focusing on studies involving male infertility worldwide during …
the first bibliometric analysis focusing on studies involving male infertility worldwide during …
Role of Macroautophagy in Mammalian Male Reproductive Physiology
Physiologically, autophagy is an evolutionarily conserved and self-degradative process in
cells. Autophagy carries out normal physiological roles throughout mammalian life …
cells. Autophagy carries out normal physiological roles throughout mammalian life …
Serum opacity factor rescues fertility among female Scarb1−/− mice by reducing HDL-free cholesterol bioavailability
C Rosales, D Yelamanchili, BK Gillard, J Liu… - Journal of Lipid …, 2023 - ASBMB
Human female infertility, 20% of which is idiopathic, is a public health problem for which
better diagnostics and therapeutics are needed. A novel cause of infertility emerged from …
better diagnostics and therapeutics are needed. A novel cause of infertility emerged from …
The effects of cholesterol metabolism on follicular development and ovarian function
Q Huang, Y Liu, Z Yang, Y Xie… - Current Molecular …, 2019 - ingentaconnect.com
Cholesterol is an important substrate for the synthesis of ovarian sex hormones and has an
important influence on follicular development. The cholesterol in follicular fluid is mainly …
important influence on follicular development. The cholesterol in follicular fluid is mainly …