Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

APE1 is an essential endodeoxyribonuclease of the base excision repair pathway that
maintains genome stability. It was identified as a pivotal factor favoring tumor progression …

The widespread accumulation of nanoplastics is a growing concern for the environmental
and human health. However, studies on the mechanisms of nanoplastic-induced …

Many cancer-associated genes are regulated by guanine (G)-rich sequences that are
capable of refolding from the canonical duplex structure to an intrastrand G-quadruplex …

The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

The base excision repair (BER) pathway is essential for maintaining the stability of DNA in
all organisms and defects in this process are associated with life-threatening diseases. It is …

The base excision repair (BER) pathway is an important defense response to oxidative DNA
damage. It is known that exposures to phthalate esters (PAEs), including Dibutyl phthalate …

Background Colorectal cancer (CRC) represents the fourth leading cause of cancer-related
deaths. The heterogeneity of CRC identity limits the usage of cell lines to study this type of …

In the era of precision medicine, radiation medicine is currently focused on the precise
delivery of highly conformal radiation treatments. However, the tremendous developments in …

Interest in RNA damage as a novel threat associated with several human pathologies is
rapidly increasing. Knowledge on damaged RNA recognition, repair, processing and decay …