Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …

Computationally identifying new targets for existing drugs has drawn much attention in drug
repurposing due to its advantages over de novo drugs, including low risk, low costs, and …

The recent pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-
CoV-2) calls the whole world into a medical emergency. For tackling Coronavirus Disease …

Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the
world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a …

Herbal medicines are often used in combination with conventional drugs, and this may give
rise to the potential of harmful herb-drug interactions. This paper updates our knowledge on …

Cytochrome P450 enzymes (CYPs) metabolize many drugs that act on the central nervous
system (CNS), such as antidepressants and antipsychotics; drugs of abuse; endogenous …

Multidrug ABC transporters such as P-glycoprotein (P-gp/MDR1/ABCB1) and multidrug
resistance protein 1 (MRP1/ABCC1) play an important role in the extrusion of drugs from the …

Clinical studies and case reports have identified a number of herb-drug interactions
potentiated by the concurrent use of herbal medicines with prescription drugs. The purpose …

Human cytochrome P450 2C9 (CYP2C9) accounts for∼ 20% of total hepatic CYP content
and metabolizes∼ 15% clinically used drugs including S-warfarin, tolbutamide, phenytoin …