The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: posttraumatic stress disorder enters the age of large-scale genomic collaboration
MW Logue, AB Amstadter, DG Baker… - …, 2015 - nature.com
The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors.
Although there have been some replicated candidates, the identification of risk variants for …
Although there have been some replicated candidates, the identification of risk variants for …
Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood
Prenatal exposure to tobacco smoke has lifelong health consequences. Epigenetic
signatures such as differences in DNA methylation (DNAm) may be a biomarker of exposure …
signatures such as differences in DNA methylation (DNAm) may be a biomarker of exposure …
Paternal adverse childhood experiences: associations with infant DNA methylation
Adverse childhood experiences (ACEs), or cumulative childhood stress exposures, such as
abuse, neglect, and household dysfunction, predict later health problems in both the …
abuse, neglect, and household dysfunction, predict later health problems in both the …
Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth
Background A recent study has shown that it is possible to accurately estimate gestational
age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn …
age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn …
Combined effects of genotype and childhood adversity shape variability of DNA methylation across age
Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk,
may be embedded via epigenetic mechanisms but findings from human studies …
may be embedded via epigenetic mechanisms but findings from human studies …
[HTML][HTML] Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications
M Tomaszewski, AP Morris, JMM Howson… - Kidney international, 2022 - Elsevier
Hypertension is a major cardiovascular disease risk factor and contributor to premature
death globally. Family-based investigations confirmed a significant heritable component of …
death globally. Family-based investigations confirmed a significant heritable component of …
The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers
Background DNA methylation is associated with body mass index (BMI), but it is not clear if
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
Epigenome-wide association study of depression symptomatology in elderly monozygotic twins
Depression is a severe and debilitating mental disorder diagnosed by evaluation of
affective, cognitive and physical depression symptoms. Severity of these symptoms strongly …
affective, cognitive and physical depression symptoms. Severity of these symptoms strongly …
Genetic variants influence on the placenta regulatory landscape
F Delahaye, C Do, Y Kong, R Ashkar, M Salas… - PLoS …, 2018 - journals.plos.org
From genomic association studies, quantitative trait loci analysis, and epigenomic mapping,
it is evident that significant efforts are necessary to define genetic-epigenetic interactions …
it is evident that significant efforts are necessary to define genetic-epigenetic interactions …
Epigenome‐wide association of PTSD from heterogeneous cohorts with a common multi‐site analysis pipeline
A Ratanatharathorn, MP Boks… - American Journal of …, 2017 - Wiley Online Library
Compelling evidence suggests that epigenetic mechanisms such as DNA methylation play a
role in stress regulation and in the etiologic basis of stress related disorders such as Post …
role in stress regulation and in the etiologic basis of stress related disorders such as Post …