For decades, lactate has been considered an innocuous bystander metabolite of cellular
metabolism. However, emerging studies show that lactate acts as a complex …

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of
cellular activities that regulate a diverse array of biological functions. They recognize two …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

Cancer and chronic infections often increase levels of the bioactive lipid, lysophosphatidic
acid (LPA), that we have demonstrated acts as an inhibitory ligand upon binding LPAR5 on …

Neuropsychiatric systemic lupus erythematosus (NPSLE) is an incurable disease
characterised by neuropsychiatric symptoms, particularly depression. Novel therapeutic …

GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory
responses. Although the precise role of GPR35 in inflammation is not yet fully understood …

Papillary carcinomas account for the largest proportion of thyroid cancers, with papillary
thyroid carcinoma (PTC) being prone to early lymph node metastasis. Some studies have …

The multi-ligand receptor for advanced glycation end-products (RAGE) and its ligands are
contributing factors in autoimmunity, cancers, and infectious disease. RAGE activation is …

Abstract Background Lysophosphatidic acids (LPAs) belong to a class of bioactive
lysophospholipids with multiple functions including immunomodulatory roles in tumor …

Multiple sclerosis (MS) is a complex inflammatory disease affecting the central nervous
system. Most commonly, it begins with recurrent symptoms followed by partial or complete …