Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of cancer with a dismal
prognosis. The lack of symptoms in the early phase of the disease makes early diagnosis …

Abstract POLE, POLD1, and NTHL1 are involved in DNA replication and have recently been
recognized as hereditary cancer-predisposing genes, because their alterations are …

Colorectal cancer (CRC) is the third most common cancer worldwide, with 1.1 million new
cases per year, and is the second leading cause of cancer death. 1 CRC occurs more …

Colorectal cancer (CRC) is the third most common tumour in men and the second in women,
accounting for 10% of all tumour types worldwide. Incidence is 25% higher in males and …

The following recommendations for post-polypectomy colonoscopic surveillance apply to all
patients who had one or more polyps that were completely removed during a high quality …

Background & Aims Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR)
in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI …

There is a growing need for systems that efficiently support the work of medical teams at the
precision-oncology point of care. Here, we present the implementation of the Molecular …

Background Determining the status of molecular pathways and key mutations in colorectal
cancer is crucial for optimal therapeutic decision making. We therefore aimed to develop a …

Hereditary cancer syndromes account for nearly 10% of cancers even though they are often
underdiagnosed. Finding a pathogenic gene variant could have dramatic implications in …

The opportunity to detect pancreatic cancer (PC) when potentially curable depends on early
diagnosis and an ability to identify and screen high-risk populations before symptoms arise …