[HTML][HTML] Recent advances in targeted therapies in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …
for younger patients over the last several decades has improved nearly sixfold with the …
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
[HTML][HTML] EVI1 dysregulation: impact on biology and therapy of myeloid malignancies
C Birdwell, W Fiskus, TM Kadia, CD DiNardo… - Blood cancer …, 2021 - nature.com
Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …
Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia
CA Lachowiez, N Long, J Saultz, A Gandhi… - Blood …, 2023 - ashpublications.org
Risk stratification in acute myeloid leukemia (AML) remains principle in survival
prognostication and treatment selection. The 2022 European LeukemiaNet (ELN) …
prognostication and treatment selection. The 2022 European LeukemiaNet (ELN) …
[HTML][HTML] The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
S Ottema, R Mulet-Lazaro… - Nature …, 2021 - nature.com
Chromosomal rearrangements are a frequent cause of oncogene deregulation in human
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …
Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia
L Smeenk, S Ottema, R Mulet-Lazaro, A Ebert… - Cancer discovery, 2021 - AACR
In acute myeloid leukemia (AML) with inv (3)(q21; q26) or t (3; 3)(q21; q26), a translocated
GATA2 enhancer drives oncogenic expression of EVI1. We generated an EVI1-GFP AML …
GATA2 enhancer drives oncogenic expression of EVI1. We generated an EVI1-GFP AML …
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients …
Abstract The European LeukemiaNet (ELN) recently proposed a revised recommendation
for the diagnosis and management of acute myeloid leukemia (AML) in adults, recognized …
for the diagnosis and management of acute myeloid leukemia (AML) in adults, recognized …
[HTML][HTML] The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
JR Schwartz, J Ma, J Kamens, T Westover… - Nature …, 2021 - nature.com
Pediatric therapy-related myeloid neoplasms (tMN) occur in children after exposure to
cytotoxic therapy and have a dismal prognosis. The somatic and germline genomic …
cytotoxic therapy and have a dismal prognosis. The somatic and germline genomic …
A novel GATA2 distal enhancer mutation results in MonoMAC syndrome in 2 second cousins
RR West, TR Bauer Jr, LM Tuschong… - Blood …, 2023 - ashpublications.org
Mutations in the transcription factor GATA2 can cause MonoMAC syndrome, a GATA2
deficiency disease characterized by several findings, including disseminated …
deficiency disease characterized by several findings, including disseminated …
The mechanism and function of super enhancer RNA
S Xiao, Q Huang, H Ren, M Yang - Genesis, 2021 - Wiley Online Library
Super enhancer (SE) is a cluster of enhancers that has a stronger ability to promote
transcription compared to the typical enhancer (TE). Similar to TE, which can transcribe …
transcription compared to the typical enhancer (TE). Similar to TE, which can transcribe …